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pubmed-article:16438715pubmed:abstractTextApproximately 40% of mammalian mRNA sequences contain AUG trinucleotides upstream of the main coding sequence, with a quarter of these AUGs demarcating open reading frames of 20 or more codons. In order to investigate whether these open reading frames may encode functional peptides, we have carried out a comparative genomic analysis of human and mouse mRNA 'untranslated regions' using sequences from the RefSeq mRNA sequence database.lld:pubmed
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pubmed-article:16438715pubmed:authorpubmed-author:WangXue-QingX...lld:pubmed
pubmed-article:16438715pubmed:authorpubmed-author:RothnagelJose...lld:pubmed
pubmed-article:16438715pubmed:authorpubmed-author:CroweMark LMLlld:pubmed
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pubmed-article:16438715pubmed:articleTitleEvidence for conservation and selection of upstream open reading frames suggests probable encoding of bioactive peptides.lld:pubmed
pubmed-article:16438715pubmed:affiliationThe Australian Research Council Special Research Centre for Functional and Applied Genomics, The University of Queensland, Brisbane, Queensland 4072, Australia. m.crowe@imb.uq.edu.aulld:pubmed
pubmed-article:16438715pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16438715pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:16438715pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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