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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2006-3-16
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pubmed:abstractText |
Approximately 40% of mammalian mRNA sequences contain AUG trinucleotides upstream of the main coding sequence, with a quarter of these AUGs demarcating open reading frames of 20 or more codons. In order to investigate whether these open reading frames may encode functional peptides, we have carried out a comparative genomic analysis of human and mouse mRNA 'untranslated regions' using sequences from the RefSeq mRNA sequence database.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16438715-10357825,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16438715-9916806
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2164
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
16
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16438715-3' Untranslated Regions,
pubmed-meshheading:16438715-5' Untranslated Regions,
pubmed-meshheading:16438715-Animals,
pubmed-meshheading:16438715-Codon,
pubmed-meshheading:16438715-Consensus Sequence,
pubmed-meshheading:16438715-Evolution, Molecular,
pubmed-meshheading:16438715-Humans,
pubmed-meshheading:16438715-Mice,
pubmed-meshheading:16438715-Mutation,
pubmed-meshheading:16438715-Open Reading Frames,
pubmed-meshheading:16438715-Peptide Chain Initiation, Translational,
pubmed-meshheading:16438715-Peptides,
pubmed-meshheading:16438715-RNA, Messenger,
pubmed-meshheading:16438715-Selection, Genetic,
pubmed-meshheading:16438715-Sequence Homology, Nucleic Acid,
pubmed-meshheading:16438715-Species Specificity
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pubmed:year |
2006
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pubmed:articleTitle |
Evidence for conservation and selection of upstream open reading frames suggests probable encoding of bioactive peptides.
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pubmed:affiliation |
The Australian Research Council Special Research Centre for Functional and Applied Genomics, The University of Queensland, Brisbane, Queensland 4072, Australia. m.crowe@imb.uq.edu.au
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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