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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-1-26
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pubmed:abstractText |
A volume-displacement counterpulsation device (CPD) intended for chronic implantation via a superficial surgical approach is proposed. The CPD is a pneumatically driven sac that fills during native heart systole and empties during diastole through a single, valveless cannula anastomosed to the subclavian artery. Computer simulation was performed to predict and compare the physiological responses of the CPD to the intraaortic balloon pump (IABP) in a clinically relevant model of early stage heart failure. The effect of device stroke volume (0-50 ml) and control modes (timing, duration, morphology) on landmark hemodynamic parameters and the LV pressure-volume relationship were investigated. Simulation results predicted that the CPD would provide hemodynamic benefits comparable to an IABP as evidenced by up to 25% augmentation of peak diastolic aortic pressure, which increases diastolic coronary perfusion by up to 34%. The CPD may also provide up to 34% reduction in LV end-diastolic pressure and 12% reduction in peak systolic aortic pressure, lowering LV workload by up to 26% and increasing cardiac output by up to 10%. This study demonstrated that the superficial CPD technique may be used acutely to achieve similar improvements in hemodynamic function as the IABP in early stage heart failure patients.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16436889-12059002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16436889-12354730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16436889-12406156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16436889-12823419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16436889-128839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16436889-14763490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16436889-15145710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16436889-15174367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16436889-15497394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16436889-15968962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16436889-3344678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16436889-8205565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16436889-8551789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16436889-8808458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16436889-9308597
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
1058-2916
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
39-46
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:16436889-Computer Simulation,
pubmed-meshheading:16436889-Counterpulsation,
pubmed-meshheading:16436889-Diastole,
pubmed-meshheading:16436889-Heart Failure,
pubmed-meshheading:16436889-Hemodynamics,
pubmed-meshheading:16436889-Intra-Aortic Balloon Pumping,
pubmed-meshheading:16436889-Models, Anatomic,
pubmed-meshheading:16436889-Stroke Volume,
pubmed-meshheading:16436889-Ventricular Function, Left
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pubmed:articleTitle |
Predicted hemodynamic benefits of counterpulsation therapy using a superficial surgical approach.
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pubmed:affiliation |
Cardiovascular Innovation Institute, Departments of Surgery and Bioengineering, University of Louisville, 500 South Floyd Street, Louisville, KY 40202, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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