Source:http://linkedlifedata.com/resource/pubmed/id/16428076
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2006-1-23
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| pubmed:abstractText |
Physalis angulata is a solanaceae widely used in folk medicine in various tropical countries in the world. We have previously described that seco-steroids (physalins) purified from P. angulata are potent inhibitors of macrophage activation, blocking the production of pro-inflammatory cytokines and LPS-induced lethality. Herein we investigated the immunomodulatory activities of these substances in lymphocyte proliferation and cytokine production and in transplantation. The addition of physalins B, F or G to concanavalin A-activated splenocyte cultures induced a concentration-dependent inhibition of proliferation. Physalin B also inhibited IL-2 production by Con A-activated spleen cells. The addition of 2 mug/ml physalin B to mixed lymphocyte reaction (MLR) caused a 100% inhibition of proliferation. More importantly, treatment of mice with physalin B, F or G prevented the rejection of allogeneic heterotopic heart transplant. Our results demonstrate the suppressive activity of physalins B, F and G in lymphocyte function and indicate the potential use of physalins as immunosuppressive agents for treatments of pathologies in which inhibition of immune responses is desired.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Concanavalin A,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Mifepristone,
http://linkedlifedata.com/resource/pubmed/chemical/Secosteroids,
http://linkedlifedata.com/resource/pubmed/chemical/physalin B,
http://linkedlifedata.com/resource/pubmed/chemical/physalin F
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1567-5769
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
6
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
408-14
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| pubmed:meshHeading |
pubmed-meshheading:16428076-Animals,
pubmed-meshheading:16428076-Cell Proliferation,
pubmed-meshheading:16428076-Concanavalin A,
pubmed-meshheading:16428076-Female,
pubmed-meshheading:16428076-Graft Rejection,
pubmed-meshheading:16428076-Heart Transplantation,
pubmed-meshheading:16428076-Immunosuppressive Agents,
pubmed-meshheading:16428076-Interleukin-2,
pubmed-meshheading:16428076-Lymphocytes,
pubmed-meshheading:16428076-Male,
pubmed-meshheading:16428076-Mice,
pubmed-meshheading:16428076-Mice, Inbred BALB C,
pubmed-meshheading:16428076-Mice, Inbred C3H,
pubmed-meshheading:16428076-Mice, Inbred C57BL,
pubmed-meshheading:16428076-Mice, Inbred CBA,
pubmed-meshheading:16428076-Mifepristone,
pubmed-meshheading:16428076-Physalis,
pubmed-meshheading:16428076-Secosteroids,
pubmed-meshheading:16428076-Spleen
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| pubmed:year |
2006
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| pubmed:articleTitle |
Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection.
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| pubmed:affiliation |
Centro de Pesquisas Gonçalo Moniz, FIOCRUZ, BA, Brazil.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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