Linked Life Data

16427268

Source:http://linkedlifedata.com/resource/pubmed/id/16427268

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-2-14
pubmed:abstractText
Synaptogenesis is a finely organized process, intriguing in its precise temporal and spatial resolution. It occurs as the dendrite of a postsynaptic neuron and an incoming axon communicate at defined sites to establish a stable synapse together. The molecular cues that guide synaptogenesis are now beginning to be identified, and cell surface interactions at synaptic sites participate prominently in the key steps. Interactions include trans-synaptic adhesion of pre- and post-synaptic neurons but also binding to non-neuronal neighboring cells and the extracellular matrix. These signals recruit scaffolding molecules, other adhesion molecules, and neurotransmitter receptors to bring together the key components of functional synapses. Recent progress provides stimulating insights into the role of adhesion and signaling molecules in the formation and function of synaptic specializations.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0959-4388
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-9
pubmed:dateRevised
2011-5-2
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Cell-cell interactions in synaptogenesis.
pubmed:affiliation
Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural