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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-1-20
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pubmed:abstractText |
The killer cell lectin-like receptor G1 (KLRG1) is expressed by NK cells and by T cells. In both humans and mice, KLRG1 identifies Ag-experienced T cells that are impaired in their proliferative capacity but are capable of performing effector functions. In this study, we identified E-cadherin as a ligand for murine KLRG1 by using fluorescently labeled, soluble tetrameric complexes of the extracellular domain of the murine KLRG1 molecule as staining reagents in expression cloning. Ectopic expression of E-cadherin in B16.BL6 target cells did not affect cell-mediated lysis by lymphokine-activated NK cells and by CD8 T cells but inhibited Ag-induced proliferation and induction of cytolytic activity of CD8 T cells. E-cadherin is expressed by normal epithelial cells, Langerhans cells, and keratinocytes and is usually down-regulated on metastatic cancer cells. KLRG1 ligation by E-cadherin in healthy tissue may thus exert an inhibitory effect on primed T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:BachmannMartin FMF,
pubmed-author:BauerMonikaM,
pubmed-author:BeckerKarl-FriedrichKF,
pubmed-author:GründemannCarstenC,
pubmed-author:HankeThomasT,
pubmed-author:KarpKlausK,
pubmed-author:LässingUteU,
pubmed-author:PircherHanspeterH,
pubmed-author:SaudanPhilippeP,
pubmed-author:SchweierOliverO,
pubmed-author:von OppenNanetteN
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
176
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1311-5
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pubmed:meshHeading |
pubmed-meshheading:16424155-Animals,
pubmed-meshheading:16424155-Antigens,
pubmed-meshheading:16424155-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16424155-Cadherins,
pubmed-meshheading:16424155-Cell Division,
pubmed-meshheading:16424155-Cell Line,
pubmed-meshheading:16424155-Growth Inhibitors,
pubmed-meshheading:16424155-Killer Cells, Lymphokine-Activated,
pubmed-meshheading:16424155-Ligands,
pubmed-meshheading:16424155-Melanoma, Experimental,
pubmed-meshheading:16424155-Mice,
pubmed-meshheading:16424155-Mice, Inbred C57BL,
pubmed-meshheading:16424155-Mice, Transgenic,
pubmed-meshheading:16424155-Receptors, Immunologic
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pubmed:year |
2006
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pubmed:articleTitle |
Cutting edge: identification of E-cadherin as a ligand for the murine killer cell lectin-like receptor G1.
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pubmed:affiliation |
Department of Immunology, Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany.
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pubmed:publicationType |
Journal Article
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