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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-1-19
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pubmed:abstractText |
In metastatic colorectal cancer, a combination of leucovorin (LV) and fluorouracil (FU) with oxaliplatin (FOLFOX) 4 is a standard first-line regimen. The cumulative neurotoxicity of oxaliplatin often requires therapy to be stopped in patients who are still responding. This study evaluates a new strategy of intermittent oxaliplatin treatment that is based on FOLFOX7, a simplified leucovorin and fluorouracil regimen with high-dose oxaliplatin.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1527-7755
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pubmed:author |
pubmed-author:AndréThierryT,
pubmed-author:BuyseMarcM,
pubmed-author:CarolaElisabethE,
pubmed-author:CervantesAndresA,
pubmed-author:ChirivellaIsabelI,
pubmed-author:EtiennePierre-LucPL,
pubmed-author:FigerArieA,
pubmed-author:FleschMichelM,
pubmed-author:LledoGérardG,
pubmed-author:LouvetChristopheC,
pubmed-author:MineurLaurentL,
pubmed-author:Perez-StaubNathalieN,
pubmed-author:RiveraFernandoF,
pubmed-author:Tabah-FischIsabelleI,
pubmed-author:TournigandChristopheC,
pubmed-author:de GramontAimeryA
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pubmed:issnType |
Electronic
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pubmed:day |
20
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
394-400
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pubmed:dateRevised |
2007-9-12
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pubmed:meshHeading |
pubmed-meshheading:16421419-Adult,
pubmed-meshheading:16421419-Aged,
pubmed-meshheading:16421419-Aged, 80 and over,
pubmed-meshheading:16421419-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:16421419-Colorectal Neoplasms,
pubmed-meshheading:16421419-Disease-Free Survival,
pubmed-meshheading:16421419-Drug Administration Schedule,
pubmed-meshheading:16421419-Female,
pubmed-meshheading:16421419-Fluorouracil,
pubmed-meshheading:16421419-Humans,
pubmed-meshheading:16421419-Leucovorin,
pubmed-meshheading:16421419-Male,
pubmed-meshheading:16421419-Middle Aged,
pubmed-meshheading:16421419-Organoplatinum Compounds,
pubmed-meshheading:16421419-Pulse Therapy, Drug,
pubmed-meshheading:16421419-Survival Analysis,
pubmed-meshheading:16421419-Treatment Outcome
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pubmed:year |
2006
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pubmed:articleTitle |
OPTIMOX1: a randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-Go fashion in advanced colorectal cancer--a GERCOR study.
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pubmed:affiliation |
Hôpital Saint-Antoine, Paris, France.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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