|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2006-1-18
|
|
pubmed:abstractText |
Mutations in the BRCA genes increase the risk of breast cancer. Valid estimates of the magnitude of the lifetime risk of breast cancer in BRCA gene mutation carriers are needed for genetic counseling. Recent results suggest that penetrance has increased in recent birth cohorts. We examined the cumulative breast cancer incidence and mortality before age 70 over a diagnosis period of 80 years in Icelandic women who carried the BRCA2 founder mutation 999del5.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1460-2105
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
18
|
|
pubmed:volume |
98
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
116-22
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16418514-Adult,
pubmed-meshheading:16418514-Aged,
pubmed-meshheading:16418514-Breast Neoplasms,
pubmed-meshheading:16418514-Female,
pubmed-meshheading:16418514-Founder Effect,
pubmed-meshheading:16418514-Genes, BRCA2,
pubmed-meshheading:16418514-Genetic Predisposition to Disease,
pubmed-meshheading:16418514-Heterozygote,
pubmed-meshheading:16418514-Humans,
pubmed-meshheading:16418514-Iceland,
pubmed-meshheading:16418514-Incidence,
pubmed-meshheading:16418514-Middle Aged,
pubmed-meshheading:16418514-Mutation,
pubmed-meshheading:16418514-Penetrance,
pubmed-meshheading:16418514-Poisson Distribution,
pubmed-meshheading:16418514-Registries,
pubmed-meshheading:16418514-Risk Assessment
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Population-based study of changing breast cancer risk in Icelandic BRCA2 mutation carriers, 1920-2000.
|
|
pubmed:affiliation |
Icelandic Cancer Registry, Skógarhlío 8, Reykjavík, Iceland. laufeyt@krabb.is
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|
