Linked Life Data

16408088

Source:http://linkedlifedata.com/resource/pubmed/id/16408088

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-1-12
pubmed:databankReference
pubmed:abstractText
Hedgehog (Hh) signaling is an important regulator of embryonic patterning, tissue regeneration, stem cell renewal and cancer growth. A purine derivative named purmorphamine was previously found to activate the Hh pathway and affect osteoblast differentiation through an unknown mechanism. We demonstrate here that purmorphamine directly targets Smoothened, a critical component of the Hh signaling pathway.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1552-4450
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
29-30
pubmed:dateRevised
2007-1-12
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
pubmed:affiliation
Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't