| pubmed-article:16407557 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16407557 | lifeskim:mentions | umls-concept:C0033640 | lld:lifeskim |
| pubmed-article:16407557 | lifeskim:mentions | umls-concept:C0123711 | lld:lifeskim |
| pubmed-article:16407557 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:16407557 | lifeskim:mentions | umls-concept:C0021666 | lld:lifeskim |
| pubmed-article:16407557 | lifeskim:mentions | umls-concept:C1519623 | lld:lifeskim |
| pubmed-article:16407557 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:16407557 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:16407557 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:16407557 | lifeskim:mentions | umls-concept:C0205099 | lld:lifeskim |
| pubmed-article:16407557 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:16407557 | lifeskim:mentions | umls-concept:C0599668 | lld:lifeskim |
| pubmed-article:16407557 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16407557 | pubmed:dateCreated | 2006-1-12 | lld:pubmed |
| pubmed-article:16407557 | pubmed:abstractText | The insulin-like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor is a single-pass transmembrane glycoprotein that plays an important role in the intracellular trafficking of lysosomal enzymes and endocytosis-mediated degradation of IGF-II. However, its role in signal transduction after IGF-II binding remains unclear. In the present study, we report that IGF-II/M6P receptor in the rat brain is coupled to a G-protein and that its activation by Leu27IGF-II, an analog that binds rather selectively to the IGF-II/M6P receptor, potentiates endogenous acetylcholine release from the rat hippocampal formation. This effect is mediated by a pertussis toxin (PTX)-sensitive GTP-binding protein and is dependent on protein kinase Calpha (PKCalpha)-induced phosphorylation of downstream substrates, myristoylated alanine-rich C kinase substrate, and growth associated protein-43. Additionally, treatment with Leu27IGF-II causes a reduction in whole-cell currents and depolarization of cholinergic basal forebrain neurons. This effect, which is blocked by an antibody against the IGF-II/M6P receptor, is also sensitive to PTX and is mediated via activation of a PKC-dependent pathway. These results together revealed for the first time that the single transmembrane domain IGF-II/M6P receptor expressed in the brain is G-protein coupled and is involved in the regulation of central cholinergic function via the activation of specific intracellular signaling cascades. | lld:pubmed |
| pubmed-article:16407557 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16407557 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16407557 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16407557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16407557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16407557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16407557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16407557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16407557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16407557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16407557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16407557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16407557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16407557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16407557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16407557 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16407557 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16407557 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:16407557 | pubmed:author | pubmed-author:KarSatyabrata... | lld:pubmed |
| pubmed-article:16407557 | pubmed:author | pubmed-author:MacDonaldRich... | lld:pubmed |
| pubmed-article:16407557 | pubmed:author | pubmed-author:JhamandasJack... | lld:pubmed |
| pubmed-article:16407557 | pubmed:author | pubmed-author:HarrisKim HKH | lld:pubmed |
| pubmed-article:16407557 | pubmed:author | pubmed-author:HawkesCherylC | lld:pubmed |
| pubmed-article:16407557 | pubmed:author | pubmed-author:FuWenW | lld:pubmed |
| pubmed-article:16407557 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16407557 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:16407557 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:16407557 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16407557 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16407557 | pubmed:pagination | 585-96 | lld:pubmed |
| pubmed-article:16407557 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:16407557 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16407557 | pubmed:articleTitle | Single transmembrane domain insulin-like growth factor-II/mannose-6-phosphate receptor regulates central cholinergic function by activating a G-protein-sensitive, protein kinase C-dependent pathway. | lld:pubmed |
| pubmed-article:16407557 | pubmed:affiliation | Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, H3A 2B4, Canada. | lld:pubmed |
| pubmed-article:16407557 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16407557 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16407557 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16407557 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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