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rdf:type |
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lifeskim:mentions |
umls-concept:C0014406,
umls-concept:C0017431,
umls-concept:C0057764,
umls-concept:C0057779,
umls-concept:C0059735,
umls-concept:C0232741,
umls-concept:C0332157,
umls-concept:C0919425,
umls-concept:C1280500,
umls-concept:C1704675,
umls-concept:C1979963,
umls-concept:C2003903
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pubmed:issue |
3-4
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pubmed:dateCreated |
2006-1-12
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pubmed:abstractText |
Previous studies reported that polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) induced hepatic cytochrome P-4501A1 (CYP1A1). The aim of this study was to examine the interactive influence of CYP1A1 genotypes and PCDD/Fs exposure on liver function profile. PCDD/Fs levels and liver function parameters were determined in serum and correlated with genetic polymorphism of CYP1A1/Msp 1 in 225 human volunteers who had no or minimal occupational exposure to PCDD/F. The results showed that the highest glutamate pyruvate transaminase (GPT) activity levels were found in subjects with homozygous variant CYP1A1/Msp 1, followed by heterozygous variant, and finally homozygous wild type for those individuals whose serum PCDD/Fs levels were higher than 17.4 pg WHO-TEQ/g lipid. Data suggest that GPT activity levels may be modified by interaction of CYP1A1/Msp 1 genotype with dioxin after adjustment for age, alcohol consumption, and history of liver illness. Further studies are needed to characterize the variation in other related genes to verify whether a correlation exists between serum PCDD/Fs levels and adverse health effects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1528-7394
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
269-81
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pubmed:meshHeading |
pubmed-meshheading:16407087-Adolescent,
pubmed-meshheading:16407087-Adult,
pubmed-meshheading:16407087-Aged,
pubmed-meshheading:16407087-Alanine Transaminase,
pubmed-meshheading:16407087-Aspartate Aminotransferases,
pubmed-meshheading:16407087-Benzofurans,
pubmed-meshheading:16407087-Cytochrome P-450 CYP1A1,
pubmed-meshheading:16407087-Environmental Monitoring,
pubmed-meshheading:16407087-Environmental Pollutants,
pubmed-meshheading:16407087-Female,
pubmed-meshheading:16407087-Genotype,
pubmed-meshheading:16407087-Humans,
pubmed-meshheading:16407087-Incineration,
pubmed-meshheading:16407087-Liver,
pubmed-meshheading:16407087-Male,
pubmed-meshheading:16407087-Middle Aged,
pubmed-meshheading:16407087-Polymorphism, Genetic,
pubmed-meshheading:16407087-Taiwan,
pubmed-meshheading:16407087-Tetrachlorodibenzodioxin
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pubmed:year |
2006
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pubmed:articleTitle |
Interactive effects between CYP1A1 genotypes and environmental polychlorinated dibenzo-p-dioxins and dibenzofurans exposures on liver function profile.
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pubmed:affiliation |
Research Center of Environmental Trace Toxic Substances, Medical College, National Cheng Kung University, Tainan, Taiwan.
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pubmed:publicationType |
Journal Article
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