Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-1-4
pubmed:abstractText
The BRCA1 gene product and its stoichiometric binding partner, BARD1, play a vital role in the cellular response to DNA damage. However, how they acquire specific biochemical functions after DNA damage is poorly understood. Following exposure to genotoxic stress, DNA damage-specific interactions were observed between BRCA1/BARD1 and the DNA damage-response proteins, TopBP1 and Mre11/Rad50/NBS1. Two distinct DNA damage-dependent super complexes emerged; their activation was dependent, in part, on the actions of specific checkpoint kinases, and each super complex contributed to a distinctive aspect of the DNA damage response. The results support a new, multifactorial model that describes how genotoxic stress enables BRCA1 to execute a diverse set of DNA damage-response functions.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-10426999, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-10477747, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-10485486, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-10506832, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-10549283, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-10550055, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-10617473, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-10635334, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-10724175, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-10783165, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-10790374, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-11100717, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-11100718, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-11114888, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-11301010, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-11313470, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-11376801, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-11395493, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-11805335, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-11809797, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-11830610, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-11832208, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-11850621, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-11877376, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-12065746, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-12086871, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-12183412, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-12438414, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-12447390, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-12598907, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-12676925, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-12743046, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-12781359, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-12792649, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-12810625, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-12855706, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-14527418, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-14576432, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-14576433, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-14576434, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-14657032, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-14701743, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-14712665, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-14982920, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-15059890, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-15242640, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-15459660, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-15485915, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-15485917, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-15536124, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-15829956, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-15829965, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-16132046, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-16153896, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-9008167, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-9267023, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-9703500, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-9766667, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-9774970, http://linkedlifedata.com/resource/pubmed/commentcorrection/16391231-9872311
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/BARD1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/BRCA1 Protein, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/DNA Repair Enzymes, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/MRE11A protein, human, http://linkedlifedata.com/resource/pubmed/chemical/NBN protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Rad50 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/TOPBP1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligases
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0890-9369
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
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