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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-12-29
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pubmed:abstractText |
The cellular inhibitor of apoptosis 2 (cIAP2/HIAP1) is a potent inhibitor of apoptotic death. In contrast to the other members of the IAP family, cIAP2 is transcriptionally inducible by nuclear factor-kappaB in response to multiple triggers. We demonstrate here that cIAP2-/- mice exhibit profound resistance to lipopolysaccharide (LPS)-induced sepsis, specifically because of an attenuated inflammatory response. We show that LPS potently upregulates cIAP2 in macrophages and that cIAP2-/- macrophages are highly susceptible to apoptosis in a LPS-induced proinflammatory environment. Hence, cIAP2 is critical in the maintenance of a normal innate immune inflammatory response.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-10201887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-10435584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-10679411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-11113565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-11313486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-11970909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-12044523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-12218091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-12672057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-12925683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-15147886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-16162163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-2071893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-2295861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-3385210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-7673742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-8183905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-8361547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-8548810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-8552191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-8642298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-8683129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-9156796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-9223320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-9441758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-9600909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16382159-9733516
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
699-708
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16382159-Animals,
pubmed-meshheading:16382159-Apoptosis,
pubmed-meshheading:16382159-Cell Survival,
pubmed-meshheading:16382159-Cells, Cultured,
pubmed-meshheading:16382159-Cytokines,
pubmed-meshheading:16382159-Immunity, Innate,
pubmed-meshheading:16382159-Inhibitor of Apoptosis Proteins,
pubmed-meshheading:16382159-Lipopolysaccharides,
pubmed-meshheading:16382159-Macrophages,
pubmed-meshheading:16382159-Mice,
pubmed-meshheading:16382159-Mice, Knockout,
pubmed-meshheading:16382159-Sepsis,
pubmed-meshheading:16382159-Up-Regulation
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pubmed:year |
2006
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pubmed:articleTitle |
Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival.
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pubmed:affiliation |
Apoptosis Research Center, Children's Hospital of Eastern Ontario, 401 Smyth Rd., Rm. R3114, Ottawa, Ontario K1H 8L1, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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