|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2006-1-4
|
|
pubmed:abstractText |
A number of distinct stress signaling pathways in myocardium cause cardiac hypertrophy and heart failure. Class II histone deacetylases (HDACs) antagonize several stress-induced pathways and hypertrophy. However, cardiac hypertrophy induced by transgenic overexpression of the homeodomain only protein, HOP, can be prevented by the nonspecific HDAC inhibitors trichostatin A and valproic acid, suggesting that alternate targets that oppose class II HDAC function might exist in myocardium. We tested the effects of several HDAC inhibitors, including a class I HDAC-selective inhibitor, SK-7041, on cardiac hypertrophy induced by angiotensin II (Ang II) treatment or aortic banding (AB).
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1524-4539
|
|
pubmed:author |
pubmed-author:AhnYoungkeunY,
pubmed-author:BangYung-JueYJ,
pubmed-author:EpsteinJonathan AJA,
pubmed-author:JeongMyung HoMH,
pubmed-author:KeeHae JinHJ,
pubmed-author:KimJong-KeunJK,
pubmed-author:KimKyung KeunKK,
pubmed-author:KimNacksungN,
pubmed-author:NamKwang IlKI,
pubmed-author:ParkJong EunJE,
pubmed-author:QianYong RiYR,
pubmed-author:SohnIl SukIS,
pubmed-author:TseLL,
pubmed-author:ZhenYunY
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
3
|
|
pubmed:volume |
113
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
51-9
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:16380549-Angiotensin II,
pubmed-meshheading:16380549-Animals,
pubmed-meshheading:16380549-Aortic Valve Stenosis,
pubmed-meshheading:16380549-Biological Markers,
pubmed-meshheading:16380549-Cardiomegaly,
pubmed-meshheading:16380549-Disease Models, Animal,
pubmed-meshheading:16380549-Drug Evaluation, Preclinical,
pubmed-meshheading:16380549-Enzyme Inhibitors,
pubmed-meshheading:16380549-Histone Deacetylase Inhibitors,
pubmed-meshheading:16380549-Male,
pubmed-meshheading:16380549-Mice,
pubmed-meshheading:16380549-Mice, Inbred Strains,
pubmed-meshheading:16380549-Rats,
pubmed-meshheading:16380549-Rats, Sprague-Dawley,
pubmed-meshheading:16380549-Treatment Outcome
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding.
|
|
pubmed:affiliation |
Department of Pharmacology, Research Institute of Medical Sciences and Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, South Korea.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
