|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001884,
umls-concept:C0005352,
umls-concept:C0007634,
umls-concept:C0038477,
umls-concept:C0205263,
umls-concept:C0441712,
umls-concept:C0996514,
umls-concept:C1518425,
umls-concept:C1521991,
umls-concept:C1709843,
umls-concept:C2603343
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|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2005-12-27
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|
pubmed:abstractText |
The inhibition of lipopolysaccharide-induced NOS by 19 bis(bibenzyls) isolated from liverworts in RAW 264.7 macrophages was evaluated. The presence of phenolic hydroxyls and saturation at 7,8 and/or 7'/8' are required for inhibition of NO production. Among the compounds tested, marchantin A was the most potent, and its inhibitory activity was consistent with the inhibition of LPS-induced iNOS mRNA.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0163-3864
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
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pubmed:volume |
68
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1779-81
|
|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:16378374-Animals,
pubmed-meshheading:16378374-Bibenzyls,
pubmed-meshheading:16378374-Cell Line,
pubmed-meshheading:16378374-Ethers, Cyclic,
pubmed-meshheading:16378374-Hepatophyta,
pubmed-meshheading:16378374-Lipopolysaccharides,
pubmed-meshheading:16378374-Macrophages,
pubmed-meshheading:16378374-Mice,
pubmed-meshheading:16378374-Molecular Structure,
pubmed-meshheading:16378374-Nitric Oxide,
pubmed-meshheading:16378374-Nitric Oxide Synthase Type II,
pubmed-meshheading:16378374-RNA, Messenger,
pubmed-meshheading:16378374-Structure-Activity Relationship
|
|
pubmed:year |
2005
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|
pubmed:articleTitle |
Bis(bibenzyls) from liverworts inhibit lipopolysaccharide-induced inducible NOS in RAW 264.7 cells: a study of structure-activity relationships and molecular mechanism.
|
|
pubmed:affiliation |
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
