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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-12-19
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pubmed:abstractText |
Nephrogenic metaplasia or nephrogenic adenoma of the urinary tract may present a diagnostic challenge in surgical pathology practice. Previous case reports suggest the possibility of nephrogenic metaplasia progressing to clear cell adenocarcinoma, but a malignant potential of nephrogenic metaplasia is generally not acknowledged. A case of a 70-year-old female patient with multiple recurrences of nephrogenic metaplasia of the urinary bladder and subsequent development of clear cell adenocarcinoma is described. Immunohistochemical studies help to differentiate the 2 entities. Results of molecular studies, particularly comparative genomic hybridization analysis, suggest clonal evolution of nephrogenic metaplasia to clear cell adenocarcinoma in this case.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0046-8177
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
117-20
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16360424-Adenocarcinoma, Clear Cell,
pubmed-meshheading:16360424-Adenoma,
pubmed-meshheading:16360424-Aged,
pubmed-meshheading:16360424-Clone Cells,
pubmed-meshheading:16360424-Cystectomy,
pubmed-meshheading:16360424-DNA, Neoplasm,
pubmed-meshheading:16360424-Disease Progression,
pubmed-meshheading:16360424-Disease-Free Survival,
pubmed-meshheading:16360424-Female,
pubmed-meshheading:16360424-Humans,
pubmed-meshheading:16360424-Loss of Heterozygosity,
pubmed-meshheading:16360424-Metaplasia,
pubmed-meshheading:16360424-Neoplasm Recurrence, Local,
pubmed-meshheading:16360424-Nucleic Acid Hybridization,
pubmed-meshheading:16360424-Precancerous Conditions,
pubmed-meshheading:16360424-Tumor Markers, Biological,
pubmed-meshheading:16360424-Urethra,
pubmed-meshheading:16360424-Urinary Bladder,
pubmed-meshheading:16360424-Urinary Bladder Neoplasms
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pubmed:year |
2006
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pubmed:articleTitle |
Molecular evidence for progression of nephrogenic metaplasia of the urinary bladder to clear cell adenocarcinoma.
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pubmed:affiliation |
Institute of Pathology, University of Regensburg, D-93042, Germany.
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pubmed:publicationType |
Journal Article,
Case Reports
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