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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-5-16
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pubmed:abstractText |
Ovarian cancer has one of the highest fractions of hereditary cases. The hereditary breast and ovarian cancer syndrome, primarily due to mutations in BRCA1 and BRCA2, is the main cause of heredity, but also the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome confers an increased risk of ovarian cancer. In order to clarify the contribution of HNPCC to the development of ovarian cancer, we collected data on family history of cancer and characterized MMR function in a consecutive series of 128 tumors unselected for age at diagnosis and previously characterized for BRCA gene mutations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Repair Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/G-T mismatch-binding protein,
http://linkedlifedata.com/resource/pubmed/chemical/MLH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MSH2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MutS Homolog 2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PMS2 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0090-8258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
238-43
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16360201-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:16360201-Adenosine Triphosphatases,
pubmed-meshheading:16360201-Adult,
pubmed-meshheading:16360201-Aged,
pubmed-meshheading:16360201-Aged, 80 and over,
pubmed-meshheading:16360201-Base Sequence,
pubmed-meshheading:16360201-Carrier Proteins,
pubmed-meshheading:16360201-Colorectal Neoplasms, Hereditary Nonpolyposis,
pubmed-meshheading:16360201-DNA Repair Enzymes,
pubmed-meshheading:16360201-DNA-Binding Proteins,
pubmed-meshheading:16360201-Female,
pubmed-meshheading:16360201-Genes, BRCA1,
pubmed-meshheading:16360201-Genes, BRCA2,
pubmed-meshheading:16360201-Germ-Line Mutation,
pubmed-meshheading:16360201-Humans,
pubmed-meshheading:16360201-Immunohistochemistry,
pubmed-meshheading:16360201-Middle Aged,
pubmed-meshheading:16360201-Molecular Sequence Data,
pubmed-meshheading:16360201-MutS Homolog 2 Protein,
pubmed-meshheading:16360201-Nuclear Proteins,
pubmed-meshheading:16360201-Ovarian Neoplasms,
pubmed-meshheading:16360201-Prospective Studies
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pubmed:year |
2006
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pubmed:articleTitle |
The contribution of the hereditary nonpolyposis colorectal cancer syndrome to the development of ovarian cancer.
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pubmed:affiliation |
Department of Oncology, Institute of Clinical Sciences, Lund University Hospital, SE-221 85 Lund, Sweden. Susanne.Malander@med.lu.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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