Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-12-19
pubmed:abstractText
Evidence from recent epidemiological studies suggests a link between periodontal infections and increased risk of atherosclerosis and related cardiovascular and cerebrovascular events in human subjects. One of the major pathogens of periodontitis, Porphyromonas gingivalis, has the ability to aggregate human platelets in platelet-rich plasma (PRP). Mechanism of P. gingivalis-induced platelet aggregation in PRP was investigated. Proteinase inhibitors toward Arg-gingipain (Rgp) and Lys-gingipain (Kgp) did not suppress P. gingivalis-induced platelet aggregation in PRP, whereas the Rgp inhibitor markedly inhibited P. gingivalis-induced platelet aggregation using washed platelets. Mutant analysis revealed that P. gingivalis-induced platelet aggregation in PRP depended on Rgp-, Kgp- and haemagglutinin A (HagA)-encoding genes that intragenically coded for adhesins such as Hgp44. Hgp44 adhesin on the bacterial cell surface, which was processed by Rgp and Kgp proteinases, was essential for P. gingivalis-induced platelet aggregation in PRP. P. gingivalis cell-reactive IgG in plasma, and FcgammaRIIa receptor and to a lesser extent GPIbalpha receptor on platelets were found to be a prerequisite for P. gingivalis-induced platelet aggregation in PRP. These results reveal a novel mechanism of platelet aggregation by P. gingivalis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adhesins, Bacterial, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD, http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Endopeptidases, http://linkedlifedata.com/resource/pubmed/chemical/Fc gamma receptor IIA, http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G, http://linkedlifedata.com/resource/pubmed/chemical/Integrin alpha2, http://linkedlifedata.com/resource/pubmed/chemical/Metalloendopeptidases, http://linkedlifedata.com/resource/pubmed/chemical/Platelet Glycoprotein GPIIb-IIIa..., http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG, http://linkedlifedata.com/resource/pubmed/chemical/Trypsin, http://linkedlifedata.com/resource/pubmed/chemical/argingipain, Porphyromonas..., http://linkedlifedata.com/resource/pubmed/chemical/mocarhagin
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0950-382X
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
152-67
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16359325-Adhesins, Bacterial, pubmed-meshheading:16359325-Animals, pubmed-meshheading:16359325-Antigens, CD, pubmed-meshheading:16359325-Bacterial Proteins, pubmed-meshheading:16359325-Blood Platelets, pubmed-meshheading:16359325-Cell Membrane, pubmed-meshheading:16359325-Cysteine Endopeptidases, pubmed-meshheading:16359325-DNA Mutational Analysis, pubmed-meshheading:16359325-Genetic Complementation Test, pubmed-meshheading:16359325-Humans, pubmed-meshheading:16359325-Immunoglobulin G, pubmed-meshheading:16359325-Integrin alpha2, pubmed-meshheading:16359325-Metalloendopeptidases, pubmed-meshheading:16359325-Periodontal Diseases, pubmed-meshheading:16359325-Plasma, pubmed-meshheading:16359325-Platelet Aggregation, pubmed-meshheading:16359325-Platelet Glycoprotein GPIIb-IIIa Complex, pubmed-meshheading:16359325-Porphyromonas gingivalis, pubmed-meshheading:16359325-Protease Inhibitors, pubmed-meshheading:16359325-Receptors, IgG, pubmed-meshheading:16359325-Trypsin
pubmed:year
2006
pubmed:articleTitle
Porphyromonas gingivalis-induced platelet aggregation in plasma depends on Hgp44 adhesin but not Rgp proteinase.
pubmed:affiliation
Division of Microbiology and Oral Infection, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't