| pubmed-article:16356633 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16356633 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:16356633 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:16356633 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:16356633 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16356633 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:16356633 | lifeskim:mentions | umls-concept:C0235032 | lld:lifeskim |
| pubmed-article:16356633 | lifeskim:mentions | umls-concept:C0025462 | lld:lifeskim |
| pubmed-article:16356633 | lifeskim:mentions | umls-concept:C0521457 | lld:lifeskim |
| pubmed-article:16356633 | lifeskim:mentions | umls-concept:C0114838 | lld:lifeskim |
| pubmed-article:16356633 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:16356633 | lifeskim:mentions | umls-concept:C0597879 | lld:lifeskim |
| pubmed-article:16356633 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:16356633 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:16356633 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:16356633 | lifeskim:mentions | umls-concept:C0961954 | lld:lifeskim |
| pubmed-article:16356633 | lifeskim:mentions | umls-concept:C1100939 | lld:lifeskim |
| pubmed-article:16356633 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16356633 | pubmed:dateCreated | 2006-2-13 | lld:pubmed |
| pubmed-article:16356633 | pubmed:abstractText | HIV-1 neurotoxic proteins (Tat, gp120) are believed to play a major role in pathogenesis of dementia in a significant portion of the AIDS patient population. Dopaminergic systems appear to be particularly important in HIV-associated dementia. In the current studies, we determined that primary cell cultures prepared from the midbrain of 18-day-old rat fetuses are sensitive to Tat neurotoxicity and investigated the possible effects of Tat on DAT-specific ligand binding and DAT immunoreactivity in rat fetal midbrain cultures. We found that Tat neurotoxicity was associated with a significant decrease in [3H]WIN 35428 binding. Immunostaining of cell cultures with antibodies recognizing the C-end epitope of DAT did not reveal significant changes in DAT immunoreactivity. The results of this study implicate involvement of monoamine transmission systems in HIV-associated dementia. | lld:pubmed |
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| pubmed-article:16356633 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16356633 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16356633 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16356633 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16356633 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16356633 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16356633 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16356633 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16356633 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:16356633 | pubmed:author | pubmed-author:BoozeRosemari... | lld:pubmed |
| pubmed-article:16356633 | pubmed:author | pubmed-author:MactutusCharl... | lld:pubmed |
| pubmed-article:16356633 | pubmed:author | pubmed-author:NathAvindraA | lld:pubmed |
| pubmed-article:16356633 | pubmed:author | pubmed-author:AksenovMichae... | lld:pubmed |
| pubmed-article:16356633 | pubmed:author | pubmed-author:SilversJanell... | lld:pubmed |
| pubmed-article:16356633 | pubmed:author | pubmed-author:RayPhilip DPD | lld:pubmed |
| pubmed-article:16356633 | pubmed:author | pubmed-author:AksenovaMarin... | lld:pubmed |
| pubmed-article:16356633 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16356633 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:16356633 | pubmed:volume | 395 | lld:pubmed |
| pubmed-article:16356633 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16356633 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16356633 | pubmed:pagination | 235-9 | lld:pubmed |
| pubmed-article:16356633 | pubmed:dateRevised | 2011-10-4 | lld:pubmed |
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| pubmed-article:16356633 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16356633 | pubmed:articleTitle | HIV-1 Tat neurotoxicity in primary cultures of rat midbrain fetal neurons: changes in dopamine transporter binding and immunoreactivity. | lld:pubmed |
| pubmed-article:16356633 | pubmed:affiliation | Department of Psychology, Program in Behavioral Neuroscience, University of South Carolina, 1512 Pendleton St, Columbia, 29208, USA. aksenova@gwm.sc.edu | lld:pubmed |
| pubmed-article:16356633 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16356633 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16356633 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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