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rdf:type |
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lifeskim:mentions |
umls-concept:C0010453,
umls-concept:C0019704,
umls-concept:C0025462,
umls-concept:C0027882,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0114838,
umls-concept:C0205225,
umls-concept:C0235032,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C0521457,
umls-concept:C0597879,
umls-concept:C0961954,
umls-concept:C1100939,
umls-concept:C1167622
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pubmed:issue |
3
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pubmed:dateCreated |
2006-2-13
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pubmed:abstractText |
HIV-1 neurotoxic proteins (Tat, gp120) are believed to play a major role in pathogenesis of dementia in a significant portion of the AIDS patient population. Dopaminergic systems appear to be particularly important in HIV-associated dementia. In the current studies, we determined that primary cell cultures prepared from the midbrain of 18-day-old rat fetuses are sensitive to Tat neurotoxicity and investigated the possible effects of Tat on DAT-specific ligand binding and DAT immunoreactivity in rat fetal midbrain cultures. We found that Tat neurotoxicity was associated with a significant decrease in [3H]WIN 35428 binding. Immunostaining of cell cultures with antibodies recognizing the C-end epitope of DAT did not reveal significant changes in DAT immunoreactivity. The results of this study implicate involvement of monoamine transmission systems in HIV-associated dementia.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/(1R-(exo,exo))-3-(4-fluorophenyl)-8-...,
http://linkedlifedata.com/resource/pubmed/chemical/Cocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Plasma Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Uptake Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, tat,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphopyruvate Hydratase,
http://linkedlifedata.com/resource/pubmed/chemical/tat Gene Products, Human...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
395
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
235-9
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pubmed:dateRevised |
2011-10-4
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pubmed:meshHeading |
pubmed-meshheading:16356633-Animals,
pubmed-meshheading:16356633-Blotting, Western,
pubmed-meshheading:16356633-Cell Survival,
pubmed-meshheading:16356633-Cells, Cultured,
pubmed-meshheading:16356633-Cocaine,
pubmed-meshheading:16356633-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:16356633-Dopamine Uptake Inhibitors,
pubmed-meshheading:16356633-Epitopes,
pubmed-meshheading:16356633-Female,
pubmed-meshheading:16356633-Gene Products, tat,
pubmed-meshheading:16356633-HIV-1,
pubmed-meshheading:16356633-Immunohistochemistry,
pubmed-meshheading:16356633-Mesencephalon,
pubmed-meshheading:16356633-Neurons,
pubmed-meshheading:16356633-Neurotoxins,
pubmed-meshheading:16356633-Phosphopyruvate Hydratase,
pubmed-meshheading:16356633-Pregnancy,
pubmed-meshheading:16356633-Protein Binding,
pubmed-meshheading:16356633-Rats,
pubmed-meshheading:16356633-Rats, Sprague-Dawley,
pubmed-meshheading:16356633-tat Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2006
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pubmed:articleTitle |
HIV-1 Tat neurotoxicity in primary cultures of rat midbrain fetal neurons: changes in dopamine transporter binding and immunoreactivity.
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pubmed:affiliation |
Department of Psychology, Program in Behavioral Neuroscience, University of South Carolina, 1512 Pendleton St, Columbia, 29208, USA. aksenova@gwm.sc.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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