| pubmed-article:16353238 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16353238 | lifeskim:mentions | umls-concept:C0001483 | lld:lifeskim |
| pubmed-article:16353238 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16353238 | lifeskim:mentions | umls-concept:C0235032 | lld:lifeskim |
| pubmed-article:16353238 | lifeskim:mentions | umls-concept:C0000098 | lld:lifeskim |
| pubmed-article:16353238 | lifeskim:mentions | umls-concept:C0038838 | lld:lifeskim |
| pubmed-article:16353238 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:16353238 | lifeskim:mentions | umls-concept:C1517499 | lld:lifeskim |
| pubmed-article:16353238 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16353238 | pubmed:dateCreated | 2006-1-25 | lld:pubmed |
| pubmed-article:16353238 | pubmed:abstractText | Oxidative stress has been suggested to be an important mediator of dopaminergic cell death in Parkinson's disease (PD). We investigated the neuroprotective potential of Cu/Zn superoxide dismutase (SOD1) overexpression in the rat substantia nigra (SN) following adenovirus-mediated gene transfer. Human dopaminergic SK-N-SH cells were transduced with adenoviral vectors expressing either human SOD1 (Ad-SOD1) or beta-galactosidase (Ad-betagal) before exposure to 1 mM of the 1-methyl-4-phenylpyridinium ion (MPP+). A strong neuroprotective effect of SOD1 gene transfer was observed in the SK-N-SH cells exposed to MPP+ compared with controls. Adult rats were then given unilateral injections of either Ad-SOD1 or Ad-betagal into the striatum, and MPP+ was administered 8 days later at the same location. Strong transgene expression was detected in the SN dopaminergic neurons, a consequence of retrograde axonal transport of the adenoviral particles. The amphetamine-induced rotational behavior of the rats was markedly lower in Ad-SOD1-injected rats than in control animals. Also, behavioral recovery significantly correlated with the number of tyrosine hydrolase-expressing neurons in the SN of the treated rats. These results are consistent with oxidative stress contributing to the MPP+ -induced neurodegenerative process. They also indicate that SOD1 gene transfer into the nigrostriatal system may be a potential neuroprotective strategy for treating PD. | lld:pubmed |
| pubmed-article:16353238 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16353238 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16353238 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16353238 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16353238 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16353238 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16353238 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16353238 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16353238 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16353238 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16353238 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16353238 | pubmed:issn | 0360-4012 | lld:pubmed |
| pubmed-article:16353238 | pubmed:author | pubmed-author:MalletJacques... | lld:pubmed |
| pubmed-article:16353238 | pubmed:author | pubmed-author:ColinPhilippe... | lld:pubmed |
| pubmed-article:16353238 | pubmed:author | pubmed-author:MillecampsSté... | lld:pubmed |
| pubmed-article:16353238 | pubmed:author | pubmed-author:BarkatsMartin... | lld:pubmed |
| pubmed-article:16353238 | pubmed:author | pubmed-author:Faucon-Biguet... | lld:pubmed |
| pubmed-article:16353238 | pubmed:author | pubmed-author:HorellouPhili... | lld:pubmed |
| pubmed-article:16353238 | pubmed:copyrightInfo | Copyright 2005 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:16353238 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16353238 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16353238 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:16353238 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16353238 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16353238 | pubmed:pagination | 233-42 | lld:pubmed |
| pubmed-article:16353238 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16353238 | pubmed:meshHeading | pubmed-meshheading:16353238... | lld:pubmed |
| pubmed-article:16353238 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16353238 | pubmed:articleTitle | 1-methyl-4-phenylpyridinium neurotoxicity is attenuated by adenoviral gene transfer of human Cu/Zn superoxide dismutase. | lld:pubmed |
| pubmed-article:16353238 | pubmed:affiliation | Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus Neurodegeneratifs (LGN), CNRS UMR 7091, Paris, France. barkats@genethon.fr | lld:pubmed |
| pubmed-article:16353238 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16353238 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16353238 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16353238 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16353238 | lld:pubmed |
