|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2006-3-23
|
|
pubmed:abstractText |
Bone marrow-derived antigen-presenting cells (APCs) play a central role in the induction of tolerance to tumor antigens expressed by B-cell lymphomas. Here we show that in vivo disruption of this APC-mediated tolerogenic mechanism unveils an intrinsic ability of malignant B cells to efficiently present tumor antigens to antigen-specific CD4+ T cells, resulting in a strong antitumor effect. This intrinsic antigen-presenting ability of malignant B cells is, however, overridden by tolerogenic bone marrow-derived APCs, leading instead to T-cell unresponsiveness and lack of antitumor effect. These results highlight the concept that therapeutic strategies aimed at enhancing the antigen-presenting function of B-cell lymphomas might not succeed unless the tolerogenic mechanisms mediated by bone marrow-derived APCs are disrupted in the first place.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-10089910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-10537110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-10662786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-11023518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-11221840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-11493453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-11516107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-12036933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-12615891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-12888794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-1439825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-14707050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-15032595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-16179369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-2492101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-3157869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-6460073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-7545296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-7681471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-7742541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-8006585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-8107800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-8436906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-8566020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-8621924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-8704200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-8956456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-9200474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-9448305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16339406-9584134
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0006-4971
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
107
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2871-8
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:16339406-Animals,
pubmed-meshheading:16339406-Antigen-Presenting Cells,
pubmed-meshheading:16339406-Cytokines,
pubmed-meshheading:16339406-Immune Tolerance,
pubmed-meshheading:16339406-Lymphocyte Activation,
pubmed-meshheading:16339406-Lymphocyte Depletion,
pubmed-meshheading:16339406-Lymphoma, B-Cell,
pubmed-meshheading:16339406-Male,
pubmed-meshheading:16339406-Mice,
pubmed-meshheading:16339406-Mice, Inbred BALB C,
pubmed-meshheading:16339406-Mice, Inbred C57BL,
pubmed-meshheading:16339406-Mice, SCID,
pubmed-meshheading:16339406-T-Lymphocytes
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
In vivo disruption of tolerogenic cross-presentation mechanisms uncovers an effective T-cell activation by B-cell lymphomas leading to antitumor immunity.
|
|
pubmed:affiliation |
Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, MRC 4 East, Rm 4072-H, 12902 Magnolia Dr, Tampa, FL 33612-9497, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
