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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-12-12
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pubmed:abstractText |
Beta(2)-adrenergic receptor (beta(2)AR) agonists are not consistently successful when administered as tocolytic therapy. The beta(2)AR displays genetic variability; an arginine-to-glycine substitution at codon 16 (Arg16Gly) has been shown to increase receptor desensitization in response to agonist exposure, whereas a substitution of glutamate for glutamine at codon 27 (Gln27Glu) decreases down-regulation. We have demonstrated that homozygosity for Arg16 protects against preterm delivery. Our goal was to determine whether beta(2)-agonists are more effective in women with the Arg16 genotype and preterm labor.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0009-9236
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
656-63
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16338281-Adrenergic beta-2 Receptor Agonists,
pubmed-meshheading:16338281-Adrenergic beta-Agonists,
pubmed-meshheading:16338281-Adult,
pubmed-meshheading:16338281-Alleles,
pubmed-meshheading:16338281-Amino Acid Substitution,
pubmed-meshheading:16338281-Arginine,
pubmed-meshheading:16338281-Female,
pubmed-meshheading:16338281-Gene Frequency,
pubmed-meshheading:16338281-Glycine,
pubmed-meshheading:16338281-Haplotypes,
pubmed-meshheading:16338281-Hexoprenaline,
pubmed-meshheading:16338281-Homozygote,
pubmed-meshheading:16338281-Humans,
pubmed-meshheading:16338281-Infant, Low Birth Weight,
pubmed-meshheading:16338281-Infant, Newborn,
pubmed-meshheading:16338281-Obstetric Labor, Premature,
pubmed-meshheading:16338281-Pregnancy,
pubmed-meshheading:16338281-Pregnancy Outcome,
pubmed-meshheading:16338281-Receptors, Adrenergic, beta-2,
pubmed-meshheading:16338281-Respiratory Distress Syndrome, Newborn,
pubmed-meshheading:16338281-Tachycardia,
pubmed-meshheading:16338281-Tocolysis,
pubmed-meshheading:16338281-Tocolytic Agents
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pubmed:year |
2005
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pubmed:articleTitle |
Arg16 homozygosity of the beta2-adrenergic receptor improves the outcome after beta2-agonist tocolysis for preterm labor.
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pubmed:affiliation |
Division of Anesthesiology and Department of Obstetrics and Gynecology, University Hospital of Geneva, University of Geneva Medical School, Geneva, Switzerland. ruth.landau@hcuge.ch
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't
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