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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-10-9
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pubmed:abstractText |
We investigated the potential effect of Cyclooxygenase-2 (Cox-2) on hypoxia-induced Angiopoietin-2 (Ang-2) expression in gastric cancer cells. Our results revealed that hypoxia augmented Cox-2 and Ang-2 expressions. Also, the hypoxia-induced Ang-2 could be mimicked by CoCl(2) treatment while genestein treatment could partially counteract the hypoxia-induced Ang-2 expression. Celecoxib but not Cox-1 inhibitor sc-560 reversed the hypoxia-induced Ang-2 expression, while this effect could be partially restored by addition of exogenous PGE2. Our findings suggest that the hypoxia-elevated Ang-2 expression in gastric cancer cells may be mediated by both Cox-2-derived PGE2 and HIF-1alpha pathways, while celecoxib could counteract the hypoxia-induced Ang-2 expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiopoietin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Angiopoietins,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/HIF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/celecoxib
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0304-3835
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pubmed:author |
pubmed-author:BaiFeihuF,
pubmed-author:DuYuleiY,
pubmed-author:FanDaimingD,
pubmed-author:FengZ PZP,
pubmed-author:HanShuangS,
pubmed-author:LichtR WRW,
pubmed-author:TaoLinL,
pubmed-author:WangJunJ,
pubmed-author:WuKaichunK,
pubmed-author:XieHuahongH,
pubmed-author:ZhaiHuihongH
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
242
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
20-7
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pubmed:meshHeading |
pubmed-meshheading:16338068-Angiopoietin-2,
pubmed-meshheading:16338068-Angiopoietins,
pubmed-meshheading:16338068-Anoxia,
pubmed-meshheading:16338068-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:16338068-Cell Line, Tumor,
pubmed-meshheading:16338068-Cyclooxygenase 2,
pubmed-meshheading:16338068-Cyclooxygenase Inhibitors,
pubmed-meshheading:16338068-Dinoprostone,
pubmed-meshheading:16338068-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16338068-Humans,
pubmed-meshheading:16338068-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:16338068-Pyrazoles,
pubmed-meshheading:16338068-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16338068-Stomach Neoplasms,
pubmed-meshheading:16338068-Sulfonamides,
pubmed-meshheading:16338068-Up-Regulation
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pubmed:year |
2006
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pubmed:articleTitle |
Celecoxib could reverse the hypoxia-induced Angiopoietin-2 upregulation in gastric cancer.
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pubmed:affiliation |
State Key Laboratory of Cancer Biology and Institute of Digestive Disease, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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