Linked Life Data

16336945

Source:http://linkedlifedata.com/resource/pubmed/id/16336945

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-1-30
pubmed:abstractText
In the developing spinal cord, early oligodendrocyte progenitor cells are induced from the ventral neural tube by the Sonic hedgehog (Shh) signal. Previous studies suggested that the Gli3 zinc finger transcription factor is an important signal transducer of Shh signaling during animal development. Here, we demonstrated that Gli3 plays a non-essential role in ventral oligodendrogenesis during normal development. However, in the absence of Shh signaling, Gli3 functions as a repressor of ventral oligodendrogenesis and ventral oligodendrogenesis is restored in Shh-/-Gli3-/- mutants. Interestingly, despite a normal production of oligodendrocyte precursor cells in the double mutants, oligodendrocyte differentiation is completely suppressed, implying that Shh signaling plays an important role in the terminal differentiation of oligodendrocytes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
1067
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
158-63
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Gli3 mutation rescues the generation, but not the differentiation, of oligodendrocytes in Shh mutants.
pubmed:affiliation
Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural