Source:http://linkedlifedata.com/resource/pubmed/id/16333651
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2005-12-26
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pubmed:abstractText |
alpha(2A)-Adrenoceptor up-regulation and supersensitivity have been described in the postmortem brains of depressed suicide victims and in the platelets of depressed subjects. The C to G transversion at nucleotide 753 (Asn to Lys change at amino acid 251 or N251K) is a low-frequency polymorphism of the alpha(2A)-adrenoceptor gene that results in a gain-of-function phenotype. A previous study has suggested an association between completed suicide and this polymorphism.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0033-3158
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
184
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
82-6
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16333651-Brain,
pubmed-meshheading:16333651-Depressive Disorder, Major,
pubmed-meshheading:16333651-Female,
pubmed-meshheading:16333651-Genetic Predisposition to Disease,
pubmed-meshheading:16333651-Humans,
pubmed-meshheading:16333651-Male,
pubmed-meshheading:16333651-Middle Aged,
pubmed-meshheading:16333651-Polymerase Chain Reaction,
pubmed-meshheading:16333651-Polymorphism, Single Nucleotide,
pubmed-meshheading:16333651-Receptors, Adrenergic, alpha-2,
pubmed-meshheading:16333651-Suicide
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pubmed:year |
2006
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pubmed:articleTitle |
The N251K functional polymorphism in the alpha(2A)-adrenoceptor gene is not associated with depression: a study in suicide completers.
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pubmed:affiliation |
Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Leioa, Bizkaia, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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