Source:http://linkedlifedata.com/resource/pubmed/id/16333523
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2006-1-25
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| pubmed:abstractText |
Increased oxidative stress has been observed to contribute the development of insulin resistance. Oxidative stress is known to increase the conversion of deoxyguanosine (dG) to 8-hydroxy-2'-deoxyguanosine (8-OHdG). Human 8-oxoguanine glycosylase (hOGG1) is the key component responsible for the removal of 8-OHdG from oxidatively damaged DNA. The repair activity of the hOGG1 Ser326Cys gene variant has been demonstrated to be lower than that of the hOGG1 Ser/Ser genotype. Therefore, the possible association of the hOGG1 Ser326Cys gene variant with insulin sensitivity was investigated in 279 normal glucose-tolerant subjects without history of cancer. Allele frequency was 21.5% for the Ser/Ser genotype (n = 60), 45.9% for the Ser/Cys genotype (n = 128), and 32.6% for the Cys/Cys genotype (n = 91). Subjects carrying the Cys/Cys genotype had significantly lower insulin sensitivity levels, assessed by homeostasis model assessment-insulin resistance (HOMA-IR), compared with the Ser/Ser and Ser/Cys genotypes (P < 0.001 and P < 0.001, respectively). In a multiple linear regression analysis, the Cys/Cys genotype was a significant determinant of HOMA-IR, independent of age, sex, body mass index, fasting plasma cholesterol, triglyceride, HDL cholesterol, LDL cholesterol, or hypertension. The present study indicates that the hOGG1 gene Cys/Cys variant is associated with a significant decrease in insulin sensitivity in subjects with normal glucose tolerance.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1434-5161
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
51
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
124-8
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16333523-Age Factors,
pubmed-meshheading:16333523-Body Mass Index,
pubmed-meshheading:16333523-DNA Glycosylases,
pubmed-meshheading:16333523-DNA Primers,
pubmed-meshheading:16333523-Female,
pubmed-meshheading:16333523-Gene Frequency,
pubmed-meshheading:16333523-Genetic Predisposition to Disease,
pubmed-meshheading:16333523-Genotype,
pubmed-meshheading:16333523-Humans,
pubmed-meshheading:16333523-Insulin Resistance,
pubmed-meshheading:16333523-Linear Models,
pubmed-meshheading:16333523-Lipids,
pubmed-meshheading:16333523-Male,
pubmed-meshheading:16333523-Oxidative Stress,
pubmed-meshheading:16333523-Polymorphism, Genetic,
pubmed-meshheading:16333523-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:16333523-Sex Factors,
pubmed-meshheading:16333523-Taiwan
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| pubmed:year |
2006
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| pubmed:articleTitle |
The hOGG1 Ser326Cys gene polymorphism is associated with decreased insulin sensitivity in subjects with normal glucose tolerance.
|
| pubmed:affiliation |
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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