Linked Life Data

16331474

Source:http://linkedlifedata.com/resource/pubmed/id/16331474

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-3-7
pubmed:abstractText
During a strain improvement program, spontaneous mutants with single or combined resistance to streptomycin (Str(r)), gentamycin (Gen(r)) or rifamycin (Rif(r)) were selected from the industrial strain of Planobispora rosea, which is the producer of thiazolylpeptide GE2270. Among the mutants resistant to each single antibiotic, higher producers occurred more frequently (60%) among Gen(r) than in Rif(r) (10%) and Str(r) (24%) populations. Two Gen(r) mutants showed up to 1.5-fold improvement in GE2270 production while single resistant mutants Str(r) and Rif(r) produced slightly more than the parental strains. The combination of Str(r) and Rif(r) in the same strain improved GE2270 yield up to 1.7-fold. Finally, a higher GE2270 producing strain (1.8-fold improvement with respect to the parental strain) was selected among those mutants with triple resistance to streptomycin, rifamycin and gentamycin. A hierarchical increase in aerial mycelium and spore formation was observed which paralleled GE2270 production improvement.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1367-5435
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
283-8
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Antibiotic production improvement in the rare actinomycete Planobispora rosea by selection of mutants resistant to the aminoglycosides streptomycin and gentamycin and to rifamycin.
pubmed:affiliation
Vicuron Pharmaceuticals, Via R. Lepetit, 34, 21040, Gerenzano (Varese), Italy. fbeltrametti@vicuron.it
pubmed:publicationType
Journal Article