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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1992-8-14
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pubmed:abstractText |
The folate receptor mediates the uptake of 5-methyltetrahydrofolate in certain cultured cells by a process called potocytosis. When these cells are grown in physiological concentrations of folate, the receptor increases the efficiency of vitamin uptake by 30-fold. We now show that PAM 212 cells, a mouse keratinocyte cell line, are unable to grow in 1 nM 5-methyltetrahydrofolate unless they express a functional folate receptor. These results suggest that under certain conditions, tissue cells in the body may depend on the folate receptor to obtain enough 5-methyltetrahydrofolate for growth.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631087-1310359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631087-13263332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631087-1739974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631087-1840502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631087-1849150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631087-1968465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631087-239003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631087-2478584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631087-2527252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631087-3417674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631087-3461471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631087-4112540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631087-6286831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631087-7107706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631087-7438101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631087-942051
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6006-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:1631087-Animals,
pubmed-meshheading:1631087-Biological Transport,
pubmed-meshheading:1631087-Carrier Proteins,
pubmed-meshheading:1631087-Cell Division,
pubmed-meshheading:1631087-Cells, Cultured,
pubmed-meshheading:1631087-Folate Receptors, GPI-Anchored,
pubmed-meshheading:1631087-Folic Acid,
pubmed-meshheading:1631087-Mice,
pubmed-meshheading:1631087-Receptors, Cell Surface,
pubmed-meshheading:1631087-Recombinant Proteins,
pubmed-meshheading:1631087-Tetrahydrofolates,
pubmed-meshheading:1631087-Transfection
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pubmed:year |
1992
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pubmed:articleTitle |
Folate receptor allows cells to grow in low concentrations of 5-methyltetrahydrofolate.
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pubmed:affiliation |
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas 75235-9039.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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