|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-3
|
|
pubmed:dateCreated |
2005-12-5
|
|
pubmed:abstractText |
This study used behavioural and in vivo electrophysiological paradigms to examine the effects of systemic and spinal administration of a bradykinin B1 receptor antagonist, compound X, on acute nociceptive responses in the rat. In behavioural experiments, compound X significantly increased the latency to withdraw the hindpaw from a radiant heat source after both intravenous and intrathecal administration, without affecting motor performance on the rotarod. In electrophysiological experiments, both intravenous and direct spinal administration of compound X attenuated the responses of single dorsal horn neurones to noxious thermal stimulation of the hindpaw. These data show that the antinociceptive effects of a bradykinin B1 receptor antagonist are mediated, at least in part, at the level of the spinal cord and suggest a role for spinal bradykinin B1 receptors in acute nociception.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0014-2999
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
19
|
|
pubmed:volume |
527
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
44-51
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:16310181-Amides,
pubmed-meshheading:16310181-Animals,
pubmed-meshheading:16310181-Carrageenan,
pubmed-meshheading:16310181-Disease Models, Animal,
pubmed-meshheading:16310181-Dose-Response Relationship, Drug,
pubmed-meshheading:16310181-Electrophysiology,
pubmed-meshheading:16310181-Foot,
pubmed-meshheading:16310181-Hindlimb,
pubmed-meshheading:16310181-Hot Temperature,
pubmed-meshheading:16310181-Hyperalgesia,
pubmed-meshheading:16310181-Hypersensitivity,
pubmed-meshheading:16310181-Injections, Intravenous,
pubmed-meshheading:16310181-Injections, Spinal,
pubmed-meshheading:16310181-Male,
pubmed-meshheading:16310181-Morphine,
pubmed-meshheading:16310181-Naphthalenes,
pubmed-meshheading:16310181-Nociceptors,
pubmed-meshheading:16310181-Pain Measurement,
pubmed-meshheading:16310181-Psychomotor Performance,
pubmed-meshheading:16310181-Pyrrolidines,
pubmed-meshheading:16310181-Rats,
pubmed-meshheading:16310181-Rats, Sprague-Dawley,
pubmed-meshheading:16310181-Receptor, Bradykinin B1,
pubmed-meshheading:16310181-Spinal Cord
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Inhibition of acute nociceptive responses in rat spinal cord by a bradykinin B1 receptor antagonist.
|
|
pubmed:affiliation |
Merck Sharp and Dohme, In Vivo Neuroscience Department, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UK. rachel_conley@merck.com
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
