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pubmed-article:16301974pubmed:abstractTextAdequate initial anticoagulant treatment is required to prevent thrombus growth and recurrence. Intravenous unfractionated heparin is being replaced by low-molecular-weight heparin as the anticoagulant of choice for initial treatment of venous thromboembolism. Vitamin K antagonists remain the only oral anticoagulant available (target international normalized ratio: 2.5). The duration of therapy should be individualized according to the risk of recurrence and the risk of bleeding. Three months of treatment is usually adequate if thrombosis was provoked by a reversible risk factor such as surgery. For patients with unprovoked ("idiopathic") thrombosis, anticoagulant treatment for at least 6 months is indicated. For patients with a recurrence of venous thromboembolism or with an irreversible risk factor such as cancer, indefinite anticoagulant therapy is recommended. Long-term treatment with low-molecular-weight heparin is usually preferable for patients with active cancer. Systemic thrombolysis is indicated for patients with massive pulmonary embolism but controversy persists for those with isolated right ventricular dysfunction.lld:pubmed
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pubmed-article:16301974pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:16301974pubmed:year2005lld:pubmed
pubmed-article:16301974pubmed:articleTitle[Treatment of venous thromboembolic disease].lld:pubmed
pubmed-article:16301974pubmed:affiliationService de pneumologie, soins intensifs, Hôpital européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Faculté de médecine Paris V René Descartes, Paris. olivier.sanchez@hop.egp.aphp.frlld:pubmed
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