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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2006-6-16
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pubmed:abstractText |
As it has been shown for Mcl-1, Bcl-xl and Bcl-2, proteins of the Bcl-2 family play a crucial role during T-cell development in the thymus. We here show that the expression of the antiapoptotic gene A1 is specifically enhanced at the DN3/DN4 transition and in DP thymocytes that have been positively selected suggesting that A1 expression might be considered as a transcriptional signature of thymocytes that have received pre-TCR or TCR survival signal. Furthermore, we observed that A1-a overexpression in recombination activation gene 1-deficient mice transgenic for the major histocompatibillity complex class I-restricted F5 TCR enhances cell survival of DP thymocytes and permits accumulation of DP cells awaiting positive selection. However, A1-a overexpression has no effect on negative selection. Therefore, our results suggest that A1 plays a specialized role in allowing survival of DP thymocytes and that its role can be distinguished from that of Mcl-1, Bcl-xl and Bcl-2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1350-9047
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1213-21
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pubmed:dateRevised |
2008-7-9
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pubmed:meshHeading |
pubmed-meshheading:16294210-Animals,
pubmed-meshheading:16294210-Apoptosis,
pubmed-meshheading:16294210-Cell Differentiation,
pubmed-meshheading:16294210-Cell Survival,
pubmed-meshheading:16294210-Cells, Cultured,
pubmed-meshheading:16294210-Flow Cytometry,
pubmed-meshheading:16294210-Gene Expression,
pubmed-meshheading:16294210-Mice,
pubmed-meshheading:16294210-Mice, Inbred C57BL,
pubmed-meshheading:16294210-Mice, Transgenic,
pubmed-meshheading:16294210-Neoplasm Proteins,
pubmed-meshheading:16294210-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:16294210-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:16294210-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16294210-T-Lymphocytes,
pubmed-meshheading:16294210-Thymus Gland,
pubmed-meshheading:16294210-bcl-X Protein
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pubmed:year |
2006
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pubmed:articleTitle |
Overexpression of the antiapoptotic protein A1 promotes the survival of double positive thymocytes awaiting positive selection.
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pubmed:affiliation |
Laboratory of homéostasie lymphocytaire, INSERM U503, IFR Biosciences Lyon-Gerland, 21 avenue Tony Garnier, 69007 Lyon, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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