| pubmed-article:16288821 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16288821 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16288821 | lifeskim:mentions | umls-concept:C0026032 | lld:lifeskim |
| pubmed-article:16288821 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:16288821 | lifeskim:mentions | umls-concept:C0206431 | lld:lifeskim |
| pubmed-article:16288821 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:16288821 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:16288821 | lifeskim:mentions | umls-concept:C2348438 | lld:lifeskim |
| pubmed-article:16288821 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:16288821 | lifeskim:mentions | umls-concept:C0164202 | lld:lifeskim |
| pubmed-article:16288821 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:16288821 | pubmed:dateCreated | 2006-2-20 | lld:pubmed |
| pubmed-article:16288821 | pubmed:abstractText | Dendritic cell (DC)-based immunotherapy has been hampered by the lack of suitable methods for antigen delivery. Here, we use biodegradable poly(D,L-lactide-co-glycolide) microspheres (PLGA-MS) as carriers of peptides and proteins for antigen delivery to human monocyte-derived DC (MoDC). Compared to soluble proteins, MHC classes I and II-restricted presentation of PLGA-MS-encapsulated proteins and peptides by MoDC was markedly prolonged and proteins were presented 50-fold more efficiently on class I molecules. The vaccination of mice with DC loaded with PLGA-MS-encapsulated proteins raised strong and persisting cytotoxic T cell responses. In conclusion, antigen delivery via PLGA-MS markedly enhanced the duration of antigen presentation by human MoDC and the potency of DC-based vaccination. | lld:pubmed |
| pubmed-article:16288821 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16288821 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16288821 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16288821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16288821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16288821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16288821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16288821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16288821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16288821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16288821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16288821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16288821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16288821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16288821 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16288821 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16288821 | pubmed:issn | 0264-410X | lld:pubmed |
| pubmed-article:16288821 | pubmed:author | pubmed-author:ScandellaElke... | lld:pubmed |
| pubmed-article:16288821 | pubmed:author | pubmed-author:MerkleHans... | lld:pubmed |
| pubmed-article:16288821 | pubmed:author | pubmed-author:GanderBrunoB | lld:pubmed |
| pubmed-article:16288821 | pubmed:author | pubmed-author:GroettrupMarc... | lld:pubmed |
| pubmed-article:16288821 | pubmed:author | pubmed-author:SchmidtkeGunt... | lld:pubmed |
| pubmed-article:16288821 | pubmed:author | pubmed-author:SchlosserEvaE | lld:pubmed |
| pubmed-article:16288821 | pubmed:author | pubmed-author:Waeckerle-Men... | lld:pubmed |
| pubmed-article:16288821 | pubmed:author | pubmed-author:AllmenEdith... | lld:pubmed |
| pubmed-article:16288821 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16288821 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:16288821 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:16288821 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16288821 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16288821 | pubmed:pagination | 1847-57 | lld:pubmed |
| pubmed-article:16288821 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:meshHeading | pubmed-meshheading:16288821... | lld:pubmed |
| pubmed-article:16288821 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16288821 | pubmed:articleTitle | Encapsulation of proteins and peptides into biodegradable poly(D,L-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells. | lld:pubmed |
| pubmed-article:16288821 | pubmed:affiliation | Research Department, Cantonal Hospital St. Gallen, CH-9007 St. Gallen, Switzerland. | lld:pubmed |
| pubmed-article:16288821 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16288821 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16288821 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16288821 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16288821 | lld:pubmed |
