Source:http://linkedlifedata.com/resource/pubmed/id/16283792
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2005-11-14
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| pubmed:abstractText |
We have developed combinatorial libraries of new 1,3-imidazoline-2-thiones 5 and 2-phenylimino-1,3-thiazolines 7 by way of different reaction sequences of the same three components, gamma-chloroacetoacetanilides 1, amines 2, and isothiocyanates 3 in a parallel synthetic fashion. One of the building blocks, the gamma-chloroacetoacetanilides 1, was prepared by the sequential reaction of 4-methylene-oxetan-2-one (ketene dimer) with chlorine and various anilines. The condensation of 1 with amines gave dihydrofuran 4 intermediates that when reacted with 3 afforded the 1,3-imidazoline-2-thiones 5. On the other hand, reaction of 3 with 2 provided substituted thioureas 6 that were reacted with 1 to yield 2-phenylimino-1,3-thiazolines 7.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:issn |
1520-4766
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
7
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
826-36
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| pubmed:articleTitle |
Syntheses of 1,3-Imidazoline-2-thione and 2-Phenylimino-1,3-thiazoline combinatorial libraries through different sequences of the same components.
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| pubmed:affiliation |
Organic Chemistry Laboratory, Korea Institute of Science and Technology, Seoul 136-791, Korea.
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| pubmed:publicationType |
Journal Article
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