Linked Life Data

16281989

Source:http://linkedlifedata.com/resource/pubmed/id/16281989

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-11-11
pubmed:abstractText
The protozoa Leishmania spp. are obligate intracellular parasites that inhabit the macrophages of their host. Since macrophages are specialized for the identification and destruction of invading pathogens, both directly and by triggering an innate immune response, Leishmania have evolved a number of mechanisms for suppressing some critical macrophage activities. In this review, we discuss how various species of Leishmania distort the host macrophage's own signalling pathways to repress the expression of various cytokines and microbicidal molecules (nitric oxide and reactive oxygen species), and antigen presentation. In particular, we describe how MAP Kinase and JAK/STAT cascades are repressed, and intracellular Ca2+ and the activities of protein tyrosine phosphatases, in particular SHP-1, are elevated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0031-1820
pubmed:author
pubmed:issnType
Print
pubmed:volume
130 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S27-35
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Subversion of host cell signalling by the protozoan parasite Leishmania.
pubmed:affiliation
Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
pubmed:publicationType
Journal Article, Review