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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2005-11-10
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pubmed:abstractText |
Angiotensinogen (AGT), the precursor of angiotensin II and a rate limiting factor in the renin-angiotensin system, is implicated in left ventricular hypertrophy, as angiotensin II is a potent stimulator of cardiac growth. A genetic variant (G-6A) in the proximal promoter region of the AGT gene may be particularly important for changes in left ventricular mass (LVM). However, previous findings associating this variant with LVM among relatively older adults with cardiovascular morbidity are inconsistent and contradictory.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0895-7061
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1437-41
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pubmed:dateRevised |
2009-2-24
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pubmed:meshHeading |
pubmed-meshheading:16280278-Adult,
pubmed-meshheading:16280278-African Americans,
pubmed-meshheading:16280278-Alleles,
pubmed-meshheading:16280278-Angiotensinogen,
pubmed-meshheading:16280278-Blood Pressure,
pubmed-meshheading:16280278-Body Mass Index,
pubmed-meshheading:16280278-Echocardiography,
pubmed-meshheading:16280278-European Continental Ancestry Group,
pubmed-meshheading:16280278-Female,
pubmed-meshheading:16280278-Gene Frequency,
pubmed-meshheading:16280278-Genotype,
pubmed-meshheading:16280278-Heart Ventricles,
pubmed-meshheading:16280278-Humans,
pubmed-meshheading:16280278-Hypertrophy, Left Ventricular,
pubmed-meshheading:16280278-Insulin Resistance,
pubmed-meshheading:16280278-Male,
pubmed-meshheading:16280278-Polymorphism, Single Nucleotide,
pubmed-meshheading:16280278-Risk Factors
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pubmed:year |
2005
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pubmed:articleTitle |
G-6A polymorphism of the angiotensinogen gene and its association with left ventricular mass in asymptomatic young adults from a biethnic community: the Bogalusa Heart Study.
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pubmed:affiliation |
Tulane Center for Cardiovascular Health, Tulane University Health Science Center, New Orleans, Louisiana 70112, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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