Source:http://linkedlifedata.com/resource/pubmed/id/16275081
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2005-11-25
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| pubmed:abstractText |
A series of acryloylamino-salicylanilides were synthesized as inhibitors of EGFR PTK. A strategy of pseudo six-membered ring formed through intramolecular hydrogen bonding in salicylanilides is employed to mimic the planar pyrimidine ring of quinazoline EGFR inhibitors. Acrylamido moiety is incorporated to target the Cys-773 of EGFR specifically. Some of the obtained compounds exhibited good activity as EGFR inhibitors.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
469-72
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:16275081-Crystallography, X-Ray,
pubmed-meshheading:16275081-Drug Design,
pubmed-meshheading:16275081-Models, Molecular,
pubmed-meshheading:16275081-Molecular Structure,
pubmed-meshheading:16275081-Protein-Tyrosine Kinases,
pubmed-meshheading:16275081-Receptor, Epidermal Growth Factor,
pubmed-meshheading:16275081-Salicylanilides,
pubmed-meshheading:16275081-Structure-Activity Relationship
|
| pubmed:year |
2006
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| pubmed:articleTitle |
Acryloylamino-salicylanilides as EGFR PTK inhibitors.
|
| pubmed:affiliation |
Department of Synthetic Medicinal Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.
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| pubmed:publicationType |
Journal Article
|