Source:http://linkedlifedata.com/resource/pubmed/id/16273115
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2006-1-11
|
| pubmed:abstractText |
Children with Philadelphia chromosome positive (Ph+) acute lymphocytic leukemia (ALL) have only a 20% event-free survival when treated with chemotherapy alone. Bone marrow transplant (BMT) for patients with matched siblings has been associated with significantly better long-term survival. We asked whether children who lack a matched sibling donor would do as well if an alternative donor was utilized. Between 1987 and 2002, we transplanted 29 children and adolescents using either an unrelated donor (23) or a mismatched family member (six). The conditioning regimen included cytosine-arabinoside, cyclophosphamide and total body irradiation. Graft-versus-host disease (GVHD) prophylaxis consisted of T-cell depletion (antibody T10B9 or OKT3 and complement) with post transplant cyclosporine (CSA). All patients engrafted. Four developed grades III-IV acute GVHD. Three of 24 evaluable patients developed extensive chronic GVHD. Two patients died of relapse (7%). Two long-term survivors (>6 years) died of malignant glioblastoma multiforme. Event-free survival at 3, 5, and 10 years is 56, 51, and 46%, respectively. Five of six patients in >CR2 or relapse at the time of transplant died. Our data should encourage the use of alternative donor transplants early in the course of disease for children with Ph+ ALL.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0268-3369
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
37
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
135-41
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16273115-Adolescent,
pubmed-meshheading:16273115-Adult,
pubmed-meshheading:16273115-Bone Marrow Transplantation,
pubmed-meshheading:16273115-Child,
pubmed-meshheading:16273115-Child, Preschool,
pubmed-meshheading:16273115-Cyclophosphamide,
pubmed-meshheading:16273115-Cytarabine,
pubmed-meshheading:16273115-Disease-Free Survival,
pubmed-meshheading:16273115-Donor Selection,
pubmed-meshheading:16273115-Female,
pubmed-meshheading:16273115-Glioblastoma,
pubmed-meshheading:16273115-Graft vs Host Disease,
pubmed-meshheading:16273115-Humans,
pubmed-meshheading:16273115-Immunosuppressive Agents,
pubmed-meshheading:16273115-Lymphocyte Depletion,
pubmed-meshheading:16273115-Male,
pubmed-meshheading:16273115-Neoplasms, Second Primary,
pubmed-meshheading:16273115-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:16273115-Prognosis,
pubmed-meshheading:16273115-Recurrence,
pubmed-meshheading:16273115-Retrospective Studies,
pubmed-meshheading:16273115-Transplantation Conditioning,
pubmed-meshheading:16273115-Whole-Body Irradiation
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Alternative donor bone marrow transplant for children with Philadelphia chromosome ALL.
|
| pubmed:affiliation |
Department of Pediatric Hematology, Oncology, Bone Marrow Transplant, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. jtalano@mcw.edu
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|