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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1992-8-13
|
| pubmed:abstractText |
Nitrofurazone (433 mg/liter drinking water) administration to leghorn laying hens for 72 hours with a 48-hour withdrawal period before nitrofurazone-sensitive Salmonella enteritidis challenge resulted in a S. enteritidis culture-positive rate significantly (P less than 0.05) higher than that of unmedicated controls when hens were cultured 6 days following challenge. In a similar experiment, simultaneous nitrofurazone administration and S. enteritidis challenge resulted in no significant differences in S. enteritidis isolation frequency. However, unchallenged nitrofurazone-medicated contact control hens showed a significantly higher S. enteritidis culture-positive rate than the unchallenged unmedicated controls. This increase in apparent S. enteritidis susceptibility was associated with significantly lower cecal propionic acid and fewer anaerobic colony-forming units (CFU). In a third experiment, nitrofurazone treatment had no effect when the antibiotic was withdrawn 72 hours before S. enteritidis challenge. In a subsequent experiment, novobiocin (385 mg/kg) or nitrofurazone (300 mg/kg) was administered to adult hens for 7 days before challenge with nitrofurazone and novobiocin-resistant S. enteritidis. Both nitrofurazone and novobiocin administration resulted in a significantly higher S. enteritidis culture-positive rate than unmedicated controls at end of the experiment 7 days post-challenge. Results indicate that administration of some antibiotics may enhance susceptibility to S. enteritidis in leghorn hens.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0005-2086
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
36
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
334-40
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1627106-Animals,
pubmed-meshheading:1627106-Bacteria, Anaerobic,
pubmed-meshheading:1627106-Cecum,
pubmed-meshheading:1627106-Chickens,
pubmed-meshheading:1627106-Fatty Acids, Volatile,
pubmed-meshheading:1627106-Female,
pubmed-meshheading:1627106-Nitrofurazone,
pubmed-meshheading:1627106-Novobiocin,
pubmed-meshheading:1627106-Poultry Diseases,
pubmed-meshheading:1627106-Salmonella Infections, Animal,
pubmed-meshheading:1627106-Salmonella enteritidis
|
| pubmed:articleTitle |
Effect of nitrofurazone or novobiocin on Salmonella enteritidis cecal colonization and organ invasion in Leghorn hens.
|
| pubmed:affiliation |
Department of Poultry Science, Texas A&M University, College Station 77843.
|
| pubmed:publicationType |
Journal Article
|