rdf:type |
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lifeskim:mentions |
|
pubmed:issue |
4
|
pubmed:dateCreated |
2005-11-4
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pubmed:abstractText |
We have shown recently that volatile anesthetics significantly decrease inflammatory cytokine production and dramatically increase survival among rodents challenged with lipopolysaccharide (LPS). Because acetylcholine's interaction with nicotine receptors on tissue macrophages during vagus nerve stimulation has been implicated in the modulation of LPS-stimulated tumor necrosis factor alpha (TNF-alpha) production, we hypothesized that the mechanism of anesthetic immunoprotection is mediated through the vagus nerve.
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pubmed:grant |
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0039-6060
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
138
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
766-71
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16269307-Anesthesia,
pubmed-meshheading:16269307-Anesthetics, Inhalation,
pubmed-meshheading:16269307-Animals,
pubmed-meshheading:16269307-Injections,
pubmed-meshheading:16269307-Interleukin-6,
pubmed-meshheading:16269307-Isoflurane,
pubmed-meshheading:16269307-Lipopolysaccharides,
pubmed-meshheading:16269307-Male,
pubmed-meshheading:16269307-Neck,
pubmed-meshheading:16269307-Rats,
pubmed-meshheading:16269307-Rats, Sprague-Dawley,
pubmed-meshheading:16269307-Shock, Septic,
pubmed-meshheading:16269307-Tumor Necrosis Factor-alpha,
pubmed-meshheading:16269307-Vagotomy,
pubmed-meshheading:16269307-Vagus Nerve
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pubmed:year |
2005
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pubmed:articleTitle |
Anesthesia-specific protection from endotoxic shock is not mediated through the vagus nerve.
|
pubmed:affiliation |
The Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
|