Source:http://linkedlifedata.com/resource/pubmed/id/16267389
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2005-11-3
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pubmed:abstractText |
Ceruloplasmin (Cp) is a copper protein with important functions in iron homeostasis and in inflammation. Cp mRNA expression is induced by interferon (IFN)-g in U937 monocytic cells, but synthesis of Cp protein is halted after about 12 h by transcript-specific translational silencing. The silencing mechanism requires binding of a 4-component cytosolic inhibitor complex, IFN-gamma-activated inhibitor of translation (GAIT), to a defined structural element (GAIT element) in the Cp 3'-UTR. Translational silencing of Cp mRNA requires the essential proteins of mRNA circularization, suggesting that the translational inhibition requires end-to-end mRNA closure. These studies describe a new mechanism of translational control, and may shed light on the role that macrophage-derived Cp plays at the intersection of iron homeostasis and inflammation.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1016-8478
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
167-72
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16267389-3' Untranslated Regions,
pubmed-meshheading:16267389-Animals,
pubmed-meshheading:16267389-Base Sequence,
pubmed-meshheading:16267389-Ceruloplasmin,
pubmed-meshheading:16267389-Gene Expression Regulation,
pubmed-meshheading:16267389-Humans,
pubmed-meshheading:16267389-Macrophages,
pubmed-meshheading:16267389-Molecular Sequence Data,
pubmed-meshheading:16267389-Protein Biosynthesis,
pubmed-meshheading:16267389-RNA, Messenger
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pubmed:year |
2005
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pubmed:articleTitle |
Regulation of macrophage ceruloplasmin gene expression: one paradigm of 3'-UTR-mediated translational control.
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pubmed:affiliation |
Department of Biology, Geology, and Environmental Sciences, Cleveland State University, Cleveland, OH, USA.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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