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rdf:type |
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lifeskim:mentions |
umls-concept:C0002351,
umls-concept:C0021027,
umls-concept:C0023434,
umls-concept:C0035696,
umls-concept:C0242656,
umls-concept:C0441889,
umls-concept:C0449438,
umls-concept:C0596611,
umls-concept:C1421567,
umls-concept:C1527940,
umls-concept:C1705831,
umls-concept:C1707455
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pubmed:issue |
11
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pubmed:dateCreated |
2005-11-3
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pubmed:abstractText |
The protein tyrosine kinase ZAP-70 has recently emerged as a major prognostic indicator in chronic lymphocytic leukemia (CLL). ZAP-70 is structurally and functionally homologous to Syk, a key mediator of B-cell receptor signaling. We therefore evaluated ZAP-70 expression in CLL B cells using Syk as an intracellular standard.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1592-8721
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pubmed:author |
pubmed-author:EfremovDimitar GDG,
pubmed-author:GobessiStefaniaS,
pubmed-author:LaurentiLucaL,
pubmed-author:LeoneGiuseppeG,
pubmed-author:MariettiSaraS,
pubmed-author:PetlickovskiAleksandarA,
pubmed-author:PiccioniPaolaP,
pubmed-author:PuggioniPierluigiP,
pubmed-author:RumiCarloC,
pubmed-author:SicaSimonaS,
pubmed-author:TarnaniMichelaM
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pubmed:issnType |
Electronic
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1533-40
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:16266901-Adult,
pubmed-meshheading:16266901-Aged,
pubmed-meshheading:16266901-Aged, 80 and over,
pubmed-meshheading:16266901-Base Sequence,
pubmed-meshheading:16266901-Disease Progression,
pubmed-meshheading:16266901-Female,
pubmed-meshheading:16266901-Genes, Immunoglobulin Heavy Chain,
pubmed-meshheading:16266901-Humans,
pubmed-meshheading:16266901-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:16266901-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:16266901-Male,
pubmed-meshheading:16266901-Middle Aged,
pubmed-meshheading:16266901-Molecular Sequence Data,
pubmed-meshheading:16266901-Mutation,
pubmed-meshheading:16266901-Protein-Tyrosine Kinases,
pubmed-meshheading:16266901-RNA, Messenger,
pubmed-meshheading:16266901-ZAP-70 Protein-Tyrosine Kinase
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pubmed:year |
2005
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pubmed:articleTitle |
Comparison of ZAP-70/Syk mRNA levels with immunoglobulin heavy-chain gene mutation status and disease progression in chronic lymphocytic leukemia.
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pubmed:affiliation |
Department of Hematology, Catholic University Hospial A. Gemelli, Rome, Italy. laurenti@rm.unicatt.it
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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