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rdf:type |
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lifeskim:mentions |
umls-concept:C0005516,
umls-concept:C0006632,
umls-concept:C0020792,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0205225,
umls-concept:C0227525,
umls-concept:C0332157,
umls-concept:C0596402,
umls-concept:C1709016,
umls-concept:C1956267
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pubmed:issue |
1
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|
pubmed:dateCreated |
2006-1-4
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|
pubmed:abstractText |
DNA microarrays can provide information about the expression levels of thousands of genes simultaneously at the transcriptomic level, while conventional cell viability and cytotoxicity measurement methods provide information about the biological functions at the cellular level. Integrating these data at different levels provides a promising approach for evaluating or predicting how cells respond to chemical exposure. It is important to investigate the multi-scale biological system in a systematic way to better understand the gene regulation networks and signal transduction pathways involved in the cellular responses to environmental factors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1367-4803
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
77-87
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16249259-Algorithms,
pubmed-meshheading:16249259-Animals,
pubmed-meshheading:16249259-Biological Markers,
pubmed-meshheading:16249259-Cadmium,
pubmed-meshheading:16249259-Computational Biology,
pubmed-meshheading:16249259-Dose-Response Relationship, Drug,
pubmed-meshheading:16249259-Gene Expression Profiling,
pubmed-meshheading:16249259-Gene Expression Regulation,
pubmed-meshheading:16249259-Hepatocytes,
pubmed-meshheading:16249259-L-Lactate Dehydrogenase,
pubmed-meshheading:16249259-Models, Theoretical,
pubmed-meshheading:16249259-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:16249259-RNA, Messenger,
pubmed-meshheading:16249259-Rats,
pubmed-meshheading:16249259-Regression Analysis,
pubmed-meshheading:16249259-Reproducibility of Results,
pubmed-meshheading:16249259-Signal Transduction,
pubmed-meshheading:16249259-Software,
pubmed-meshheading:16249259-Time Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Integrating time-course microarray gene expression profiles with cytotoxicity for identification of biomarkers in primary rat hepatocytes exposed to cadmium.
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pubmed:affiliation |
Cedars-Sinai Research Institute, Cedars-Sinai Medical Center Los Angeles, CA 90048, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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