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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2005-10-21
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pubmed:abstractText |
Cellular immunity mediated by T lymphocytes, in particular CD4+ and CD8+ type 1 cells, is the main defense against pathogenic fungi. Here, CD28-deficient (CD28-/-) mice were used to study the role of costimulation for the generation and maintenance of T-cell-mediated, type 1 cytokine-dependent mechanisms of vaccine immunity to Blastomyces dermatitidis infection. Disruption of CD28 costimulation reduced the number of type 1 CD4 and CD8 cells generated and impaired resistance to infection. Type 1 T-cell subsets generated in vaccinated CD28-/- mice were durable and protected mice for at least 3 months after vaccination. Our findings suggest that CD28 is required for the induction of optimal, protective T-cell responses to B. dermatitidis infection but may be dispensable for the maintenance of T-cell memory.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-10209038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-10477604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-10660460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-10880526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-11104791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-11134274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-11698427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-11937529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-11994440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-12096029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-12370335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-12471131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-12574376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-12782709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-12974476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-15130503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-2540528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-5338131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-646221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-7399670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-7530013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-7546205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-7688139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-7882171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-8752911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-8758893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-8781268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-9010717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-9016874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-9064340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-9126966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-9743331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16239544-9834052
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7436-41
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16239544-Animals,
pubmed-meshheading:16239544-Antigens, CD28,
pubmed-meshheading:16239544-Blastomyces,
pubmed-meshheading:16239544-Blastomycosis,
pubmed-meshheading:16239544-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16239544-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16239544-Cytokines,
pubmed-meshheading:16239544-Fungal Vaccines,
pubmed-meshheading:16239544-Immunologic Memory,
pubmed-meshheading:16239544-Male,
pubmed-meshheading:16239544-Mice,
pubmed-meshheading:16239544-Mice, Inbred C57BL,
pubmed-meshheading:16239544-Mice, Knockout
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pubmed:year |
2005
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pubmed:articleTitle |
CD28 is required for optimal induction, but not maintenance, of vaccine-induced immunity to Blastomyces dermatitidis.
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pubmed:affiliation |
University of Wisconsin Hospitals and Clinics, 600 Highland Ave., K4/444, Madison, WI 53792, USA. mwuethri@wisc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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