Linked Life Data

16225968

Source:http://linkedlifedata.com/resource/pubmed/id/16225968

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2006-2-14
pubmed:abstractText
Since antigen-persistence plays a role for induction of immunity, we investigated the in vivo pharmacokinetic of a naked DNA vaccine at the site of its action, i.e., in the lymph node. After direct intralymphatic injection, naked DNA vaccine degraded within a few hours. In correlation with the short persistence of the DNA vaccine we found that the frequency of vaccination critically influenced the strength of the immune response. In mice vaccinated every 3 days, cytotoxic T-cell responses were enhanced compared to immunization in 6 or 9 days intervals. The results suggest that the so far disappointing efficiency of naked DNA vaccines in humans may be overcome by more frequent vaccination.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0264-410X
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1389-94
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Critical role for DNA vaccination frequency in induction of antigen-specific cytotoxic responses.
pubmed:affiliation
Unit for Experimental Immunotherapy, University Hospital of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland.
pubmed:publicationType
Journal Article