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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-3-2
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pubmed:abstractText |
Granulocyte--colony-stimulating factor administered for autologous hematopoietic stem cell isolation from blood may favor restenosis in patients implanted after acute myocardial infarction (AMI). We therefore tested the isolation of peripheral-blood CD34+ cells without mobilization in six patients with AMI. After large-volume cytapheresis and positive CD34+ cell selection, 3.6 to 27.6 million CD34+ cells were obtained. We performed intra-coronary implantation of these cells and recorded no restenosis or arrhythmia. We used positron emission tomography (PET) to assess myocardial-labeled CD34+ cell homing, which accounted for 5.5% of injected cells 1 hour after implantation. In conclusion, large amounts of CD34+ cells, in the range reported in previous studies, can be obtained from nonmobilized peripheral blood. PET with [18F]-fluorodeoxyglucose cell labeling is an efficient imaging method for homing assessment.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1066-5099
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pubmed:author |
pubmed-author:BerkenboomGuyG,
pubmed-author:BlockletDidierD,
pubmed-author:DegauteJean-PaulJP,
pubmed-author:EgriseDominiqueD,
pubmed-author:GoldmanMichelM,
pubmed-author:GoldmanSergeS,
pubmed-author:LambermontMichelineM,
pubmed-author:PreumontNicolasN,
pubmed-author:StoupelEricE,
pubmed-author:ToungouzMichelM,
pubmed-author:UngerPhilippeP
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
333-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16223854-Adult,
pubmed-meshheading:16223854-Aged,
pubmed-meshheading:16223854-Antigens, CD34,
pubmed-meshheading:16223854-Cell Movement,
pubmed-meshheading:16223854-Coronary Restenosis,
pubmed-meshheading:16223854-Coronary Vessels,
pubmed-meshheading:16223854-Feasibility Studies,
pubmed-meshheading:16223854-Female,
pubmed-meshheading:16223854-Follow-Up Studies,
pubmed-meshheading:16223854-Hematopoietic Stem Cell Mobilization,
pubmed-meshheading:16223854-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:16223854-Hematopoietic Stem Cells,
pubmed-meshheading:16223854-Humans,
pubmed-meshheading:16223854-Male,
pubmed-meshheading:16223854-Middle Aged,
pubmed-meshheading:16223854-Myocardial Infarction,
pubmed-meshheading:16223854-Myocardium,
pubmed-meshheading:16223854-Positron-Emission Tomography,
pubmed-meshheading:16223854-Radionuclide Imaging
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pubmed:year |
2006
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pubmed:articleTitle |
Myocardial homing of nonmobilized peripheral-blood CD34+ cells after intracoronary injection.
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pubmed:affiliation |
Department of Nuclear Medicine and PET/Biomedical Cyclotron Unit, Hôpital Universitaire Erasme, Université Libre de Bruxelles, Brussels, Belgium. dblockle@ulb.ac.be
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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