Source:http://linkedlifedata.com/resource/pubmed/id/16220288
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2006-5-10
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| pubmed:abstractText |
The objectives of this study were to determine genotypic and allelic frequencies of macrophage migration inhibitory factor (MIF) gene -173 G/C polymorphism in patients with juvenile rheumatoid arthritis (JRA) and to evaluate the association of the MIF -173 C allele with the outcome of JRA. Genomic DNA was collected from 67 JRA patients and 153 healthy individuals. To evaluate the association of the MIF -173 polymorphism with the outcome, we analyzed the data concerning the treatment regimen, duration of glucocorticoid treatment, score on the childhood health assessment questionnaire (C-HAQ) and the number of joints with active arthritis. Nonsignificant differences were observed between the study and control groups in the distribution of genotype and allele frequencies of the MIF gene -173 G/C polymorphism. In JRA patients, carrying a MIF -173 C allele, the number of disease modifying antirheumatic drugs required for the treatment was more, the duration of glucocorticoid treatment was significantly longer, and at the last visits the C-HAQ scores and the number of joints with active arthritis were significantly higher. MIF gene -173 C allele frequency did not differ between the controls and JRA patients. MIF -173 C allele did not confer increased susceptibility to JRA in our study group. Carriage of the MIF -173 C allele was found to be a strong predictor of poor outcome in all types of JRA.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
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| pubmed:issn |
0172-8172
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
26
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
726-31
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| pubmed:meshHeading |
pubmed-meshheading:16220288-Alleles,
pubmed-meshheading:16220288-Arthritis, Juvenile Rheumatoid,
pubmed-meshheading:16220288-Case-Control Studies,
pubmed-meshheading:16220288-Child,
pubmed-meshheading:16220288-Child, Preschool,
pubmed-meshheading:16220288-Female,
pubmed-meshheading:16220288-Follow-Up Studies,
pubmed-meshheading:16220288-Gene Frequency,
pubmed-meshheading:16220288-Glucocorticoids,
pubmed-meshheading:16220288-Heterozygote,
pubmed-meshheading:16220288-Humans,
pubmed-meshheading:16220288-Macrophage Migration-Inhibitory Factors,
pubmed-meshheading:16220288-Male,
pubmed-meshheading:16220288-Polymorphism, Genetic,
pubmed-meshheading:16220288-Prognosis,
pubmed-meshheading:16220288-Time Factors,
pubmed-meshheading:16220288-Treatment Outcome,
pubmed-meshheading:16220288-Turkey
|
| pubmed:year |
2006
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| pubmed:articleTitle |
Association of macrophage migration inhibitory factor gene -173 G/C polymorphism with prognosis in Turkish children with juvenile rheumatoid arthritis.
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| pubmed:affiliation |
Department of Pediatrics, Laboratory of Molecular Medicine, Ege University School of Medicine, Bornova, 35100, SSK Tepecik Hospital, Izmir, Turkey. afig@med.ege.edu.tr
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| pubmed:publicationType |
Journal Article,
Comparative Study
|