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rdf:type |
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lifeskim:mentions |
umls-concept:C0004891,
umls-concept:C0031727,
umls-concept:C0033681,
umls-concept:C0033684,
umls-concept:C0205102,
umls-concept:C0282535,
umls-concept:C0851285,
umls-concept:C1418576,
umls-concept:C1418577,
umls-concept:C1423080,
umls-concept:C1423613,
umls-concept:C1704675,
umls-concept:C1711351,
umls-concept:C1882071
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pubmed:issue |
10
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pubmed:dateCreated |
2005-10-12
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pubmed:abstractText |
BCR/ABL fusion tyrosine kinase is responsible for the initiation and maintenance of the Philadelphia chromosome-positive chronic myelogenous leukemia (CML) and a cohort of acute lymphocytic leukemias. We show that a signaling protein, phosphatidylinositol-3 kinase (PI-3k), is essential for growth of CML cells, but not of normal hematopoietic cells, and that p85alpha subunit of PI-3k co-immunoprecipitates with BCR/ABL. Therefore, we made an attempt to better characterize p85alpha-BCR/ABL interactions.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0301-472X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1222-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16219545-Amino Acid Substitution,
pubmed-meshheading:16219545-Animals,
pubmed-meshheading:16219545-Cell Line, Tumor,
pubmed-meshheading:16219545-Fusion Proteins, bcr-abl,
pubmed-meshheading:16219545-Hematopoietic Stem Cells,
pubmed-meshheading:16219545-Humans,
pubmed-meshheading:16219545-Immunoprecipitation,
pubmed-meshheading:16219545-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:16219545-Mice,
pubmed-meshheading:16219545-Mutagenesis, Site-Directed,
pubmed-meshheading:16219545-Philadelphia Chromosome,
pubmed-meshheading:16219545-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:16219545-Point Mutation,
pubmed-meshheading:16219545-Protein Binding,
pubmed-meshheading:16219545-Protein Subunits,
pubmed-meshheading:16219545-Protein-Tyrosine Kinases,
pubmed-meshheading:16219545-Proto-Oncogene Proteins,
pubmed-meshheading:16219545-Signal Transduction,
pubmed-meshheading:16219545-src Homology Domains
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pubmed:year |
2005
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pubmed:articleTitle |
Intrinsic regulation of the interactions between the SH3 domain of p85 subunit of phosphatidylinositol-3 kinase and the protein network of BCR/ABL oncogenic tyrosine kinase.
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pubmed:affiliation |
Center for Biotechnology, College of Science and Technology, Temple University, 1900 N. 12th St, Philadelphia, PA 19122, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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