Most of the cannabinoids in Cannabis sativa L. have not been fully evaluated for their pharmacological activity. A publication in this issue presents evidence that a plant cannabinoid, Delta(9)-tetrahydrocannabivarin is a potent antagonist of anandamide, a major endogenous cannabinoid. It seems possible that many of the non-psychoactive constituents of this plant will be of biological interest.
Department of Medicinal Chemistry and Natural Products, Faculty of Medicine, Hebrew University, Ein Kerem Campus, Jerusalem 91120, Israel. mechou@cc.huji.ac.il
