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pubmed:abstractText |
Unfractionated heparin reduces metastasis in many murine models. Multiple mechanisms are proposed, particularly anticoagulation and/or inhibition of P-selectin and L-selectin. However, the doses used are not clinically tolerable and other heparins are now commonly used. We studied metastasis inhibition by clinically relevant levels of various heparins and investigated the structural basis for selectin inhibition differences.
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pubmed:affiliation |
Glycobiology Research and Training Center, Department of Medicine, Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California 92093-0687, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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